System diseases 2

A.A. 2018/2019
12
Crediti massimi
144
Ore totali
SSD
BIO/12 MED/07 MED/08 MED/10 MED/15 MED/36
Lingua
Inglese
Programma e organizzazione didattica

Edizione unica

Informazioni sul programma
Programma d'insegnamento:
CLINICAL BIOCHEMISTRY
· Lecture 1. Clinical Enzymology
· Lecture 2. Diagnostic tools in clinical laboratory for disease onset and progression. Real Time PCR
· Lecture 3. Diagnostic tools in clinical laboratory for disease onset and progression; test Elisa
· Lecture 4. High throughput technologies toward personalized medicine; contribution to patient stratification and monitoring
· Lecture 5. Hypoxia adaptation: molecular mechanisms and monitoring
· Lecture 6. Sarcopenia and cachexia: the relevance of muscle mass loss in metabolic disorder, cancer and aging.

RESPIRATORY DISEASES
· Lecture 1. Pulmonary function tests and imaging
· Lecture 2. Chronic Obstructive Pulmonary Disease - COPD
· Lecture 3. Asthma
· Lecture 4. Diffuse parenchymal lung diseases (DPLD)
· Lecture 5. Obstructive and Restrictive lung diseases. Pulmonary Infections
· Lecture 6. Respiratory infections, including pneumonia
· Lecture 7. Respiratory diseases and microbial infection
· Lecture 8. Tuberculosis (TB), Latent TB Infection (LTBI) and non-tuberculous mycobacteria (NTM)
· Lecture 9. Bronchiectasis (Bx) and Cystic Fibrosis (CF)
· Lecture 10. Sleep and Sleep disorders
· Lecture 11. Pulmonary Vascular Diseases (PVDs)
· Lecture 12. Thoracic Tumours (TT)
· Lecture 13. Tumours of the lung and pleura
· Lecture 14. Molecular Pathology of lung cancer
· Lecture 15. Pleural diseases
· Lecture 16. Acute and chronic respiratory failure (RF)
· Case studies

HEMATOLOGY
· Lecture 1. Introduction to the course
· Lecture 2. Overview of hemostasis and thrombosis
· Lecture 3. Bleeding syndromes
· Lecture 4. Thrombotic disorders and thrombotic microangiopathies
· Lecture 5. Imaging of thrombosis and pulmonary thromboembolism and related interventional procedures - intravascular thrombolysis, vena cava filters
· Lecture 6. Principles of erythropoiesis and hypo-regenerative anemias
· Lecture 7. Hemoglobinopathies, red cell enzymopathies and membrane disorders
· Lecture 8. Hemolitic anemias and transfusional medicine
· Lecture 9. Ph-negative and Ph+ myeloproliferative syndromes
· Lecture 10. Acute myeloid and lymphoid leukemias
· Lecture 11. Myelodysplastic and bone marrow failure syndromes
· Lecture 12. Plasma cell disorders
· Lecture 13. Microbes and hematologic diseases
· Lecture 14 - Lymphoid neoplasms I part
· Lecture 15 - Lymphoid neoplasms II part
· Lecture 16. Clinical approach to lymphadenopathies and splenomegaly
· Lecture 17. Hodgkin Lymphoma
· Lecture 18. Non-Hodgkin lymphomas
· Lecture 19. Chronic lymphoid leukemia
· Lecture 20. Infections in the pathogenesis of hematological neoplasms
· Lecture 21.PET in the staging and restaging of lymphomas
· Lecture 22. Types and indications to bone marrow transplantation
· Lecture 23. Infections in the immunocompromised host
· Lecture 24. The role of bone marrow biopsy in the diagnosis of myeloid neoplasms
· Lecture 25. Normal hemopoeisis and bone marrow microenvironment, including laboratory techniques in
· Lecture 26. From theory to practice
· Lecture 27. From theory to practice
· Lecture 28. From theory to practice: approach to hematological emergencies


Bibliografia di riferimento
· Harrison's Principles of Internal Medicine, 19th Edition, McGraw Hill, 2015 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Robbins and Cotran. Pathologic Basis Of Disease (9th Edition)
· Medical Microbiology, 8th edition. P. Murray, K Rosenthal, A. Pfaller Elsevier
· Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Burtis & Bruns, 7th Edition, Elsevier
· Essential of Radiology. F. A. Mettler. 3rd Edition. Elsevier Saunders (ebook)
· Core Radiology. J. Mandell. Cambrige University Press. (ebook)
· Teaching material from the individual lectures
· Website: www.uptodate.com
Prerequisiti e modalità di esame
Modalità di erogazione del corso di insegnamento
· Lectures
· Clinical cases
· Case studies
· Laboratory skills

Modalità di svolgimento dell'esame di profitto
Student assessment is based on a combination of written and oral examinations.
The written exam is a multiple choice test focused on the topics of the modules: Clinical Biochemistry, Microbiology, Pathology. Only students who successfully pass the written test for all the subjects are allowed to take the oral examination, focused on the following modules: Diagnostic Imaging, Respiratory Diseases, Blood Diseases.
The final mark is the weighted average of the marks obtained through the oral examinations.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 4
Lezioni: 48 ore

Clinical biochemistry
BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA - CFU: 1
Lezioni: 12 ore
Docente: Gelfi Cecilia

Microbiology
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA - CFU: 1
Lezioni: 12 ore

Pathology
MED/08 - ANATOMIA PATOLOGICA - CFU: 1
Lezioni: 12 ore

Radiology
MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA - CFU: 1
Lezioni: 12 ore

Respiratory diseases
MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO - CFU: 4
Lezioni: 48 ore

Siti didattici
Docente/i
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Medicina Nucleare - Polo San Paolo
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Presso UOC di Ematologia e Medicina Trasfusionale, AO L. Sacco e Polo Uuniversitario
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Lunedì dalle 10 alle 13
LITA
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U.O.C. Anatomia Patologica, Pad. Bosisio 1° piano, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Via F. Sforza 35, Milano
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pad. Granelli Osp. Maggiore Policlinico - CTMO
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Lunedì 12.00-13.00
Servizio Interaziendale di Anatomia Patologica, Polo Scientifico e Tecnologico, Via Fantoli 16/15, 20138 Milano
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UOC Pneumologia, Ospedale L. Sacco, Via G.B. Grassi, 74 - Milano
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IRCCS Istituto Ortopedico Galeazzi, Radiologia, piano -2