Cancer immunology (ONC)

A.A. 2017/2018
Insegnamento per
6
Crediti massimi
42
Ore totali
SSD
MED/04 MED/06 MED/15
Lingua
Inglese
Obiettivi formativi
Acquisition of immunosurveillance and immunoevasion concepts, knowledge of the biological basis of the most tumor escape mechanisms, understanding of the biological rational understanding of the most used approaches for the modulation of the immune response with anti-cancer purposes.
Specific knowledge on the relationship between the host's immune system and the tumor and the main anti-tumor approaches based on immunomodulatory strategies.

Struttura insegnamento e programma

Edizione attiva
Responsabile
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore

General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 2
Lezioni: 14 ore

Medical oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore

Prerequisiti e modalità di esame
Acute and chronic inflammation, the immune system, tumor immunogenicity, molecular pathogenesis of solid and hematological malignancies.
Test based on a series of questions
General pathology and immunology
Programma
The immune system in the tumor microenvironment:
Inflammation in tumor progression;
Functional role of tumor-associated leukocytes and other host cells;
Immune infiltrate and tumor angiogenesis;
Effects of the tumor on local and systemic immune regulation;
Tumor-associated regulatory T cells;
Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN);
Tertiary lymphoid structures in the tumor;
Therapeutic approaches targeting the tumor microenvironment.
Materiale didattico e bibliografia
PDF files of the lessons. Review article on different topics.
Medical oncology
Programma
Cancer immunology and immunotherapy in solid tumors:
History and principles of immune cancer treatment;
Predictors of response to immune therapies;
Development of anticancer immune agents;
Evidence of efficacy of immune therapies;
Immunotherapies in different models of solid cancers;
T-cell therapies;
Cancer vaccines;
Future trends in cancer immune therapy;
Toxicity of cancer immune therapies;
Sustainability of anticancer agents.
Materiale didattico e bibliografia
PDF files of the lessons. Review article on different topics.
Blood diseases
Programma
Cancer immunology and immunotherapy in hematological tumors:
The role of checkpoint inhibitors in Lymphomas;
Adoptive immunotherapy for cancer (CAR T cells);
Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer;
The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma;
The role of the B-cell receptor signaling in lymphoid malignancies.
Materiale didattico e bibliografia
PDF files of the lessons. Review article on different topics.
Periodo
Terzo trimestre
Periodo
Terzo trimestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi
Docente/i
Ricevimento:
Appuntamento su richiesta telefonica o via email
Dipartimento di Scienze della Salute, Ospedale San Paolo, via di Rudinì 8, Milano. Blocco C, 7° piano.
Ricevimento:
previo appuntamento da concordare via e-mail
Ricevimento:
martedì pomeriggio dalle 17 alle 18 previa conferma telefonica allo 0223903066
Istituto Nazionale dei Tumori - via G. Venezian, 1
Ricevimento:
previo appuntamento da concordare via e-mail
Laboratori area Pieve c/o Istituto Clinico Humanitas
Ricevimento:
previo appuntamento da concordare via e-mail
Ricevimento:
su appuntamento +39 02 6444.2291
Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano