Epidemiology, pathogenesis and diagnostics of cancer

A.A. 2017/2018
Insegnamento per
6
Crediti massimi
42
Ore totali
SSD
MED/01 MED/04 MED/06 MED/15
Lingua
Inglese
Obiettivi formativi
The training course aims to transfer to the students the basic knowledge of tumors pathogenesis and diagnosis, with particular reference to the development of the epidemiology, pathology and medical genetics notions and their applications to the diagnosis and therapy of tumors.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
growth
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
Epidemiology of cancer
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors

Struttura insegnamento e programma

Edizione attiva
Responsabile
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore
Docenti: Carniti Cristiana, Neri Antonino

General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 1
Lezioni: 7 ore

Medical Oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore

Medical statistics
MED/01 - STATISTICA MEDICA - CFU: 1
Lezioni: 7 ore

Prerequisiti e modalità di esame
Principles of tumorigenesis: causes and modality
Genetic instability, deregulated cell proliferation and survival of cancer cell
Key deregulated molecular pathways
Molecular diagnostic tools
Multiple Choice Test Questions
Medical statistics
Programma
Patterns and trends of cancer mortality in Europe.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
Materiale didattico e bibliografia
Pdf files of presentations. Review article on different topics.
General pathology and immunology
Programma
Cancer Stem Cells:
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated secretory phenotype.
Materiale didattico e bibliografia
Pdf files of presentations. Review article on different topics.
Medical Oncology
Programma
Natural history of solid cancer; Cancer clinical methodology; Building state of the art in oncology;
Principles of cancer multidisciplinary treatment; Principles of medical cancer treatment; Biology-driven therapy in solid cancer: the model of colon cancer; Molecularly targeted therapy: the model of GIST.
Materiale didattico e bibliografia
Pdf files of presentations. Review article on different topics.
Blood diseases
Programma
Molecular and biological mechanisms of acute and chronic myeloid disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Materiale didattico e bibliografia
Pdf files of presentations. Review article on different topics.
Periodo
Terzo trimestre
Periodo
Terzo trimestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi
Docente/i
Ricevimento:
su appuntamento via email
Fondazione IRCCS Istituto Nazionale Tumori (3° piano, Blocco E), via G. Venezian 1, Milano
Ricevimento:
Appuntamento su richiesta telefonica o via email
Dipartimento di Scienze della Salute, Ospedale San Paolo, via di Rudinì 8, Milano. Blocco C, 7° piano.
Ricevimento:
martedì 14.00-17.00
Via A. Vanzetti, 5 20133 Milano
Ricevimento:
previo appuntamento da concordare via e-mail
Ricevimento:
su appuntamento +39 02 6444.2291
Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano