Experimental immunology and immunobiotechnology

A.A. 2018/2019
Insegnamento per
6
Crediti
42
Ore totali
SSD
MED/04 MED/16 MED/46 VET/05
Lingua
Inglese
Obiettivi formativi
The course aims at providing a general understanding of potentials and limitations of experimental immunology approaches to the understanding on molecular and cellular mechanisms underlying human immunopathology, here developed approaching a selection of immunological diseases as cases of study.
The students will learn how to investigate on the pathogenesis of models of human diseases starting from the unanswered clinical and biological questions. The knowledge of the advanced biotechnologies and of animal models will make it possible to understand what technical tools and approaches are currently available to disclose the cellular and molecular mechanisms of human diseases.
Edizione unica
Edizione attiva
Responsabile
Moduli o unità didattiche
Domestic animal infectious diseases
VET/05 - MALATTIE INFETTIVE DEGLI ANIMALI DOMESTICI - CFU: 2
Lezioni: 14 ore
Docente: Riva Federica

General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 1
Lezioni: 7 ore
Docente: Locati Massimo

Laboratory medicine
MED/46 - SCIENZE TECNICHE DI MEDICINA DI LABORATORIO - CFU: 2
Lezioni: 14 ore

Reumatology
MED/16 - REUMATOLOGIA - CFU: 1
Lezioni: 7 ore

Prerequisiti e modalità di esame
At the end of the course, each student will be asked to present and discuss with the class and the faculty the original data in a joined session. Every presentation will be scored and will serve as the final oral examination of the course.
Students can register to give the final exam only after they will be approved for all the courses comprise in the COMMON LEARNING ACTIVITY track of the Medical Biotechnology and Molecular Medicine Master Degree.
The exam is oral as detailed in the step 4 and 5 of the program to assess the knowledge and understanding of the students in regard to the lessons, assigned research articles and different aspects of the above-mentioned human immunologic diseases.
General pathology and immunology
Programma
Potential and Limitations of modern biotechnologies to be used to investigate on the pathogenesis of the above-mentioned autoimmune diseases (Flow Cytometry - Omics - Gene Therapies - Approaches of Translational Medicine).
Materiale didattico e bibliografia
Slides produced during the course.
Material provided or suggested by the teachers.
Gene Targeting: a practical approach, ed. A.I. Joyner Oxford University Press - Benessere e Animal Care dell'Animale da Laboratorio, ed Point Veterinaire Italie
Reumatology
Programma
Lessons introducing the current knowledge in regard to the physiopathology of the following auto-immune diseases:
a) Systemic Lupus Erythematosus (SLE);
b) Antiphospholipid Syndrome (APS);
c) Systemic Sclerosis (SSc);
d) Vasculitis. (Cellular and molecular mechanisms - Biomarkers and autoantibodies - Novel therapeutic approaches - Transplant in autoimmunity - Biological Therapies).
Materiale didattico e bibliografia
Slides produced during the course.
Material provided or suggested by the teachers.
Gene Targeting: a practical approach, ed. A.I. Joyner Oxford University Press - Benessere e Animal Care dell'Animale da Laboratorio, ed Point Veterinaire Italie
Laboratory medicine
Programma
Each student will be asked to focus on a specific aspect related to experimental immunology and immunobiotechnology implications for each defined theme working on a selection of research articles indicated by the Faculty. This step will be developed in a series of meetings with the tutor.
Materiale didattico e bibliografia
Slides produced during the course.
Material provided or suggested by the teachers.
Gene Targeting: a practical approach, ed. A.I. Joyner Oxford University Press - Benessere e Animal Care dell'Animale da Laboratorio, ed Point Veterinaire Italie
Domestic animal infectious diseases
Programma
Potential and Limitations of the murine models associated to the above-mentioned autoimmune disorders (Production and analysis of transgenic animals - Gene targeting technologies - Production and analysis of knock out animals - Conditional gene targeting - In vivo experiment planning - Legislation - Models of experimental pathology in autoimmunity and transplantation - Production and analysis of bone marrow chimeras - Xenografts and humanized mice).
Materiale didattico e bibliografia
Slides produced during the course.
Material provided or suggested by the teachers.
Gene Targeting: a practical approach, ed. A.I. Joyner Oxford University Press - Benessere e Animal Care dell'Animale da Laboratorio, ed Point Veterinaire Italie
Periodo
Terzo trimestre
Periodo
Terzo trimestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi
Docente/i
Ricevimento:
previo appuntamento da concordare via e-mail
Laboratori area Pieve c/o Istituto Clinico Humanitas
Ricevimento:
Previo Appuntamento
Istituto Clinico Humanitas, Via Alessandro Manzoni 113, Rozzano, Milano
Ricevimento:
su appuntamento
via Celoria 10
Ricevimento:
Previo appuntamento da concordare via e-mail
IRCCS Humanitas, CCP piano III, via A. Manzoni 56, Rozzano (MI)