Morphological and molecular basis of the central nervous system and its pathologies

A.A. 2018/2019
Insegnamento per
8
Crediti massimi
60
Ore totali
SSD
VET/01 VET/03
Lingua
Inglese
Obiettivi formativi
The course aims to provide an understanding of aspects related to the two main integrative systems of the body, the nervous and endocrine systems. Anatomy, function and hormonal regulation of Central and Peripheral Nervous System is covered with developmental anatomy added when applicable.
The course will also provide information about pathogenesis of the most important neurological diseases, and on the animal models that are used for their study and comprehension.

Struttura insegnamento e programma

Edizione attiva
Responsabile
Moduli o unità didattiche
Unit: Molecular pathology of the CNS
VET/01 - ANATOMIA DEGLI ANIMALI DOMESTICI - CFU: 0
VET/03 - PATOLOGIA GENERALE E ANATOMIA PATOLOGICA VETERINARIA - CFU: 0
Esercitazioni: 12 ore
Lezioni: 12 ore

Unit: Morphology and Function of the CNS
VET/01 - ANATOMIA DEGLI ANIMALI DOMESTICI - CFU: 0
VET/03 - PATOLOGIA GENERALE E ANATOMIA PATOLOGICA VETERINARIA - CFU: 0
Esercitazioni: 12 ore
Lezioni: 24 ore
Docente: Brevini Tiziana

STUDENTI FREQUENTANTI
Informazioni sul programma
L'apprendimento degli aspetti relativi al sistema nervoso. L'anatomia, la funzione e la regolazione del Sistema Nervoso Centrale e Periferico sono trattate in dettaglio e allargate allo sviluppo fetale embrionale e fetale dei sistemi stessi. Le Patologie trattate includono la mallattia di Alzheimer, la malattia di Parkinson, le prionosi e la sclerosi multipla, che verranno discusse per quello che riguarda la patogenesi ed i principali modelli animali utilizzati.
Prerequisiti e modalità di esame
written exam
Unit: Morphology and Function of the CNS
Programma
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Metodi didattici
lectures and practices
Materiale didattico e bibliografia
Handouts
Unit: Molecular pathology of the CNS
Programma
LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

PRACTICES
Histopathology of the main brain and Peripheral nervous tissue
Purification and activation of blood monocytes as model for working with brain mononuclear cells
Metodi didattici
lectures and practices
Materiale didattico e bibliografia
Handouts will be available to students through ARIEL platform
STUDENTI NON FREQUENTANTI
Prerequisiti e modalità di esame
Written exam
Unit: Morphology and Function of the CNS
Programma
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Materiale didattico e bibliografia
Handouts
Unit: Molecular pathology of the CNS
Programma
LECTURES
Lecture 1: ageing
Lecture 2: Brain inflammation
Lecture 3: Muscular Dystrophy
Lecture 4: Prion diseases
Lecture 5: Alzheimer disease
Lecture 6: Parkinson disease
Lecture 7: Multiple Sclerosis

PRACTICES
Papers describing in details the histopathological and molecular lesion in the Central and Peripheral nervous system will be uploaded onto ARIEL platform and provided to the students
Materiale didattico e bibliografia
Handouts will be available to students through ARIEL platform
Periodo
Secondo semestre
Periodo
Secondo semestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi
Docente/i
Ricevimento:
tutti i giorni previo appuntamento
Ricevimento:
Tutti i giorni previo appuntamento
Dipartimento di Medicina Veterinaria