Biomarkers in animal models

A.A. 2018/2019
Insegnamento per
8
Crediti massimi
48
Ore totali
SSD
AGR/18 AGR/19 VET/05
Lingua
Inglese
Obiettivi formativi
The course addresses methods and techniques that are used in biomarkers defining and validation in different fields

Struttura insegnamento e programma

Edizione attiva
Responsabile
Moduli o unità didattiche
Module: Biomarkers in animal nutrition
AGR/18 - NUTRIZIONE E ALIMENTAZIONE ANIMALE - CFU: 3
Lezioni: 18 ore

Module: Diagnostic tools in animal infectious diseases
VET/05 - MALATTIE INFETTIVE DEGLI ANIMALI DOMESTICI - CFU: 3
Lezioni: 18 ore

Module: Laboratory techniques to test DNA-damage in animal models
AGR/19 - ZOOTECNIA SPECIALE - CFU: 2
Lezioni: 12 ore

STUDENTI FREQUENTANTI
Informazioni sul programma
The course addresses methods, tools and techniques that are used in animal science for health and nutritional evaluation
Propedeuticità
those suggested by the SBV couse
Prerequisiti e modalità di esame
Final examination will consist in a presentation that addresses the use of biomarkers in animal models.

The course will help the student in getting familiar with the main biomarkers that are relevant in animal science.
Metodi didattici
lectures, lab activisties, visits, seminars.
Module: Diagnostic tools in animal infectious diseases
Programma
Aim of these lessons is description of the main bacterial, fungal and viral infectious diseases and the tools for the identification of causative agents
Metodi didattici
Oral presentations
Materiale didattico e bibliografia
Slides
Module: Laboratory techniques to test DNA-damage in animal models
Programma
Lectures
Causes and occurrence of oxidative stress damage (3 hours).
Evaluation of total anti-oxidant capacity and repairing mechanisms (2 hours).
Application of biomarkers for the screening and monitoring of oxidative status (2 hours)
Development of DNA adducts, DNA repair pathways and assessment of oxidized bases in cellular DNA (3 hours).
Identification of valid and reliable biomarkers in monitoring oxidative status in biological systems (2 hours).
Metodi didattici
Lectures
Materiale didattico e bibliografia
Materials and teacher 's presentation used during lectures are available in Ariel.
Books
DNA adducts: formation, detection, and mutagenesis. Ed. Emerson Alvarez and Roberto Cunha. Publisher Nova Science Publishers Inc. 2010.
Davies, K.J.A. and Ursini, F., eds. (1996) The Oxygen Paradox, 811 pages, CLEUP University Press, Padova (Italy) ISBN: 8871783743; ISBN 13: 9788871783741
Module: Biomarkers in animal nutrition
Programma
Aim of the course:
the course addresses the use of biomarkers of nutritional exposure and nutritional status. Different type of biochemical and functional index of status of an essential nutrient or other dietary constituents will be studied. The goal is to critically evaluate the state of the science of biomarkes of nutritional intake in animal models.

COURSE ORGANIZATION :
lectures (16h)

Nutritional behavior
Nutritional status evaluation
Micronutrient status biomarkers

Practice training (16h)
Laboratory activities
Journal club

Final examination
A seminar on a specific topic related to the course contents

Books
·Biomarkers of nutritional exposure and nutritional status. J.Nutrition 2003 Vol 133. 3S demies Press
Metodi didattici
lectures and journal club mainly.
Materiale didattico e bibliografia
http://ariel.unimi.it/

Biomarkers of nutritional exposure and nutritional status. J.Nutrition 2003 Vol 133. 3S demies Press
STUDENTI NON FREQUENTANTI
Prerequisiti e modalità di esame
Final examination will consist in a presentation that addresses the use of biomarkers in animal models.

The course will help the student in getting familiar with the main biomarkers that are relevant in animal science.
Module: Diagnostic tools in animal infectious diseases
Programma
This course is only for frequenting students
Materiale didattico e bibliografia
This course is only for frequenting students
Module: Laboratory techniques to test DNA-damage in animal models
Programma
Lectures
Causes and occurrence of oxidative stress damage (3 hours).
Evaluation of total anti-oxidant capacity and repairing mechanisms (2 hours).
Application of biomarkers for the screening and monitoring of oxidative status (2 hours)
Development of DNA adducts, DNA repair pathways and assessment of oxidized bases in cellular DNA (3 hours).
Identification of valid and reliable biomarkers in monitoring oxidative status in biological systems (2 hours).
Materiale didattico e bibliografia
Materials and teacher 's presentation used during lectures are available in Ariel.
Books
DNA adducts: formation, detection, and mutagenesis. Ed. Emerson Alvarez and Roberto Cunha. Publisher Nova Science Publishers Inc. 2010.
Davies, K.J.A. and Ursini, F., eds. (1996) The Oxygen Paradox, 811 pages, CLEUP University Press, Padova (Italy) ISBN: 8871783743; ISBN 13: 9788871783741
Module: Biomarkers in animal nutrition
Programma
Aim of the course:
the course addresses the use of biomarkers of nutritional exposure and nutritional status. Different type of biochemical and functional index of status of an essential nutrient or other dietary constituents will be studied. The goal is to critically evaluate the state of the science of biomarkes of nutritional intake in animal models.

COURSE ORGANIZATION :
lectures (16h)

Nutritional behavior
Nutritional status evaluation
Micronutrient status biomarkers

Further knowledge
Methods in nutritional biomarkers evaluation
Principles of NMR


Final examination
A seminar on a specific topic related to the course contents

Books
· Biomarkers of nutritional exposure and nutritional status. J.Nutrition 2003 Vol 133. 3S demies Press
Materiale didattico e bibliografia
http://ariel.unimi.it/

Biomarkers of nutritional exposure and nutritional status. J.Nutrition 2003 Vol 133. 3S demies Press
Periodo
Secondo semestre
Periodo
Secondo semestre
Modalità di valutazione
Esame
Giudizio di valutazione
voto verbalizzato in trentesimi