Grazioso Giovanni

PROFESSORE ASSOCIATO
SSD
CHIM/08 - CHIMICA FARMACEUTICA
Settore concorsuale
03/D1 - CHIMICA E TECNOLOGIE FARMACEUTICHE, TOSSICOLOGICHE E NUTRACEUTICO-ALIMENTARI

Contatti

Sede di lavoro

Via Mangiagalli, 25
20133 MILANO (MI)

Numero di telefono dell'ufficio
02503 19352
Altri numeri di telefono
0250319351
E-mail di ateneo
Venerdì 10.30 -12.30, previo appuntamento
Luogo di ricevimento
Uff. 2015 - Lab. 2053 - II piano - Via Mangiagalli 25

Didattica

Ricerca

Pubblicazioni
  • Computationally Driven Structure Optimization, Synthesis, and Biological Evaluation of Imidazole-Based Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Inhibitors / C. Lammi, J. Sgrignani, A. Arnoldi, G. Lesma, C. Spatti, A. Silvani, G. Grazioso. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 62:13(2019 Jun 18), pp. 6163-6174.
  • Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer / A. Spinello, S. Martini, F. Berti, M. Pennati, M. Pavlin, J. Sgrignani, G. Grazioso, G. Colombo, N. Zaffaroni, A. Magistrato. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 168(2019 Apr 15), pp. 253-262.
  • Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity / C. Lammi, J. Sgrignani, A. Arnoldi, G. Grazioso. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019 Feb 20).
  • Inhibition of PCSK9D374Y/LDLR Protein–Protein Interaction by Computationally Designed T9 Lupin Peptide / C. Lammi, J. Sgrignani, G. Roda, A. Arnoldi, G. Grazioso. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - (2018 Dec 03). [Epub ahead of print]
  • First Food-Derived Peptide Inhibitor of the Protein-Protein Interaction between Gain-of-Function PCSK9D374Y and the Low-Density Lipoprotein Receptor / G. Grazioso, C. Bollati, S. Jacopo, A. Arnoldi, C. Lammi. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 66:40(2018 Oct 10), pp. 10552-10557.