Advanced molecular biology
A.A. 2018/2019
Obiettivi formativi
The course of Advanced Molecular Biology aims at providing a deep overview of the mechanisms controlling cell division and proliferation and how the cell cycle mechanisms are integrated with processes required to maintain the integrity of the genome. These topics will be discussed in model organims and in mammalian cells, with a particular focus on human pathologies linked to alterations in the molecular mechanisms of these processes.
Risultati apprendimento attesi
Non definiti
Periodo: Primo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Programma
- The Cell Cycle
- Model organisms in the cell cycle analysis
- The cell cycle control systems
- The control of S phase
- Molecular mechanisms and control of mitosis
- Completion of mitosis and cell division
- Control of cell proliferation and growth
- Processes that compromise genome integrity
- DNA repair and DNA damage tolerance mechanisms
- Pathologies related to increased genome instability
- Cell cycle checkpoints in physiological and pathological conditions
- The cell cycle in cancer and other human diseases.
- Mechanisms responsible for the maintenance of genome integrity as targets for anticancer therapy
- Model organisms in the cell cycle analysis
- The cell cycle control systems
- The control of S phase
- Molecular mechanisms and control of mitosis
- Completion of mitosis and cell division
- Control of cell proliferation and growth
- Processes that compromise genome integrity
- DNA repair and DNA damage tolerance mechanisms
- Pathologies related to increased genome instability
- Cell cycle checkpoints in physiological and pathological conditions
- The cell cycle in cancer and other human diseases.
- Mechanisms responsible for the maintenance of genome integrity as targets for anticancer therapy
Informazioni sul programma
Copies of the slides used during the lectures will be available through the Ariel platform
Prerequisiti
Good knowledge of Molecular Biology, Genetics and Biochemistry is required.
Written exam (open questions); students that regularly attend the course will have the possibility to go through an intermediate exam covering approximately half the program and then a final exam at the end of the course.
Written exam (open questions); students that regularly attend the course will have the possibility to go through an intermediate exam covering approximately half the program and then a final exam at the end of the course.
Metodi didattici
Traditional lectures supported by slides
Regular attendance is strongly suggested.
Regular attendance is strongly suggested.
Materiale di riferimento
-D.O. Morgan. The Cell Cycle: principles of control New Science Press.
-Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A. & Ellenberger, T. DNA repair and mutagenesis (ASM Press).
-Friedberg E.C., Elledge S.J, Lehmann A.R., Lindahl T., Muzi Falconi M. DNA Repair, Mutagenesis, and Other Responses to DNA Damage: A Subject Collection from Cold Spring Harbor Perspectives in Biology
Scientific papers and reviews will be indicated during the course
-Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A. & Ellenberger, T. DNA repair and mutagenesis (ASM Press).
-Friedberg E.C., Elledge S.J, Lehmann A.R., Lindahl T., Muzi Falconi M. DNA Repair, Mutagenesis, and Other Responses to DNA Damage: A Subject Collection from Cold Spring Harbor Perspectives in Biology
Scientific papers and reviews will be indicated during the course
Docente/i
Ricevimento:
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