Protein biochemistry
A.A. 2018/2019
Obiettivi formativi
Protein Biochemistry explores, with advanced level depth, the structural and functional features that support the many and varied activities of proteins in the cell. The course includes theoretical bases of protein structure, activity and dynamics, examples from diseases related to protein misfolding and dysfunction, and molecular medicine, and covers some of the main cellular processes that are linked to protein synthesis, turnover, proteotoxicicty and regulation.
Risultati apprendimento attesi
Non definiti
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Programma
Starting from the fundamental properties of proteins, the course will explore their destinations and behaviour in the context of protein synthesis, of protein folding, misfolding and aggregation (with hints at proteotoxicicty and misfolding diseases). In particular, recovery of misfolded proteins through chaperones and chaperonins will be analyzed. Processes related to protein turnover and proteolytic digestion will be explored, through detailed analysis of the ubiquitin/proteasome system, lysosome digestion, autophagy and the unfolded protein response from the ER. Apoptosis and related cellular processes will be also covered.
Tutorials: According to the arguments dealt with, reference to specific book chapters (e.g from Voet & Voet - BIOCHEMISTRY, 3rd Edition, Wiley ) or to literature reviews will be presented to the students. Given the advanced level of the course, this multi-docs/literature approach is a component of the instruction that should be conveyed.
Tutorials: According to the arguments dealt with, reference to specific book chapters (e.g from Voet & Voet - BIOCHEMISTRY, 3rd Edition, Wiley ) or to literature reviews will be presented to the students. Given the advanced level of the course, this multi-docs/literature approach is a component of the instruction that should be conveyed.
Informazioni sul programma
contact: [email protected], or see the course web site (link below).
Propedeuticità
Solid background in biochemistry, introductory biophysics and cell biology.
Prerequisiti
Examinations consist of a written test based on open questions on topics covered by the lectures. Students that issue a seminar during the second half of the Course will undergo a reduced written test, and their final score will be an average of the seminar and written test scores.
Metodi didattici
The Protein Biochemistry course is organized as a combination of front lectures, seminars by external speakers, and (optional) seminars presented by the students. The front-desk lectures (Prof. Martino Bolognesi) will cover about 75% of the teaching activity, following the topics covered by the course program. 25% will be covered by external lecturers and students literature seminars.
Materiale di riferimento
Lecture slides will be available on the ARIEL web page http://mbolognesibp.ariel.ctu.unimi.it
BIO/10 - BIOCHIMICA - CFU: 6
Lezioni: 48 ore
Docente:
Bolognesi Martino