Signal transduction
A.A. 2018/2019
Obiettivi formativi
To provide the students with the cultural and methodological tools for the critical analysis, and the understanding, of the molecular mechanisms of signal transduction.
Risultati apprendimento attesi
Non definiti
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Programma
This course focuses on mechanisms of intracellular signal transduction in eukaryotes. We will analyze specific topics on several well-characterized signaling pathways, and important, useful experimental approaches to study signal transduction. We will compare conserved and not conserved aspects during evolution. The course will also have in-depth discussion of specific topics in the signaling field.
Unit 1 (Gnesutta) 3 cfu
General principles of signal transduction
Signaling by Tyrosine kinase receptors: the Insulin receptor
mTOR signaling and translational control
Cellular and molecular responses to cell stress signals
Critical analysis of research articles related to the course's topics
Unit 2 (Costa) 3 cfu
Ca2+ as a second messenger
How the Ca2+ concentration is fine regulated inside the cell. Examples of the roles played by Ca2+ transporters and channels in developmental processes and in response to environmental stimuli in plant cells
Role of Ca2+ in the response of environmental stimuli, both abiotic and biotic
Ca2+ decoding mechanisms and their role in developmental and environmental responses processes. Kinases and Ca2+ binding proteins
"Sensor relays" and "sensor responders"
Second messengers' crosstalk. Ca2+ and reactive oxygen and nitrogen species (ROS and NOS) in the mechanisms of local and systemic signalisation
The different topics will be presented by a detailed analysis of fundamental research papers in the field of signal transduction
Unit 1 (Gnesutta) 3 cfu
General principles of signal transduction
Signaling by Tyrosine kinase receptors: the Insulin receptor
mTOR signaling and translational control
Cellular and molecular responses to cell stress signals
Critical analysis of research articles related to the course's topics
Unit 2 (Costa) 3 cfu
Ca2+ as a second messenger
How the Ca2+ concentration is fine regulated inside the cell. Examples of the roles played by Ca2+ transporters and channels in developmental processes and in response to environmental stimuli in plant cells
Role of Ca2+ in the response of environmental stimuli, both abiotic and biotic
Ca2+ decoding mechanisms and their role in developmental and environmental responses processes. Kinases and Ca2+ binding proteins
"Sensor relays" and "sensor responders"
Second messengers' crosstalk. Ca2+ and reactive oxygen and nitrogen species (ROS and NOS) in the mechanisms of local and systemic signalisation
The different topics will be presented by a detailed analysis of fundamental research papers in the field of signal transduction
Informazioni sul programma
Powerpoint slides and original papers will be made available on the dedicated Ariel website.
Propedeuticità
None
Prerequisiti
Good knowledge of molecular and cell biology is highly recommended. Knowledge of mammalian and plant biology is also recommended.
Exam modality
Oral. For each Unit of the course, students will have to critically analyse, in the form of an oral presentation, a scientific paper chosen among the ones made available by the teachers. The presentation, consisting in a short introduction of the biological problem, and the critical analysis of the experiments reported in the paper, will be followed by discussion with the teacher on the signaling mechanisms analysed in the research article and during the course. The students will be also evaluated based on the theoretical knowledge of the different topics presented during the course. Teachers will raise specific questions at a dedicated test session, or at the time of the article presentation.
Exam modality
Oral. For each Unit of the course, students will have to critically analyse, in the form of an oral presentation, a scientific paper chosen among the ones made available by the teachers. The presentation, consisting in a short introduction of the biological problem, and the critical analysis of the experiments reported in the paper, will be followed by discussion with the teacher on the signaling mechanisms analysed in the research article and during the course. The students will be also evaluated based on the theoretical knowledge of the different topics presented during the course. Teachers will raise specific questions at a dedicated test session, or at the time of the article presentation.
Metodi didattici
The classes will have a classical format with lessons given by the teachers during which the students can actively participate with questions and comments related to the considered subject.
Course attendance is highly recommended.
Course attendance is highly recommended.
Materiale di riferimento
All the material used for the classes will be made available at the dedicated Ariel website.
BIO/04 - FISIOLOGIA VEGETALE
BIO/10 - BIOCHIMICA
BIO/10 - BIOCHIMICA
Lezioni: 48 ore
Docenti:
Costa Alex, Gnesutta Nerina Bruna
Docente/i
Ricevimento:
Giovedì 14:00-16:00
Dipartimento di Bioscienze 3° Piano Torre C
Ricevimento:
martedi' 11.30-12.30 per appuntamento via email
7C