Clinical oncology and radiotherapy

A.A. 2019/2020
7
Crediti massimi
84
Ore totali
SSD
BIO/14 M-PSI/01 MED/06 MED/08 MED/36
Lingua
Inglese
Obiettivi formativi
The course id designed with a multidisciplinary approach integrating clinical concology,chemotherapy, radiotherapy and psychology to address clical approach to oncologic patients.
During the course students will
-acquire the clinical "vocabulary" of clinical oncology, in order for students, whether as future general practioners or as non-cancer specialists, to be able to discuss cancer clinical cases with an oncology team on a multidisciplinary basis and/or to be proactive in counseling patients on treatment options in collaboration with an oncology team;
- to advise patients on their lifestyles supporting behavioral change motivation, and early diagnosis choices, to properly refer patients when suspected or diagnosed with cancer or cancer risk, to share patient follow-up and surveillance with cancer institutions;
- to be able to appreciate and start managing cancer-related emergencies and to share management of patients major complications from cancer and/or cancer treatment.
- to acquire knowledge on the role of Molecular Pathology in oncology, spanning from implication of cancer molecular and morphological heterogeneity in acquired resistance to targeted therapies, to precision medicine, liquid biopsy, and basic principles of cancer genomics including an overview of the latest techniques and experimental models used in Pathology Divisions.
- to acquire knowledge on the role of radiotherapy (RT) in the management of cancer: biological basis of RT, indications, combination with other cancer therapies (multimodality approach, multidisciplinary treatment), basic technical issues (modern high-precision RT: intensity modulated RT IMRT, image-guided RT IGRT, stereotactic RT SRT, intraoperative RT IORT, brachytherapy etc.), fractionation, dose and volume concept, acute and late toxicity, management of RT-induced toxicity, tumor response evaluation, role of RT in 4 big killers (lung, prostate, breast, colon-rectum). Imaging in oncology and in particular in radiation oncology.
Risultati apprendimento attesi
At the end of the course students are expected to know: Basic knowledge about epidemiology of cancer, etiology and pathogenesis of thoracic and gastrointestinal malignancies
Programma e organizzazione didattica

Edizione unica

Prerequisiti
To take the Clinical Oncology and Radiotherapy exam, students must have already passed all the exams of the first and second year (Fundamentals of Basic Sciences, Cells, Molecules and Genes 1 and 2, Human Body, Functions and Mechanisms of Diseases).
Modalità di verifica dell’apprendimento e criteri di valutazione
The examination is based on a multiple-choice test (56 questions, each one with only one correct answer). Test duration: 90 minutes. Each correct answer corresponds to 0.55 points (no penalties will be given to missing or wrong answers). The final mark is the sum of the points obtained in each question.
The exam is deemed to be passed successfully if the final grade is equal to or higher than 18/30. If the number of correct questions exceeds 54, honors (lode) is granted.
Registration to the exam through SIFA is mandatory.
Medical oncology
Programma
Lecture 1. "Clinical biology" of cancer
Lecture 2. Precision medicine in molecular pathology
Lecture 3. Cancer screening, early diagnosis and follow-up
Lecture 4. Principles of immunopathology
Lecture 5. Molecular pathology of breast cancer
Lecture 6. Molecular pathology of cancers of the female genital tract
Lecture 7. Molecular pathology of gastrointestinal cancers
Lecture 8. Clinical methodology in Oncology
Lecture 9. Principles of multidisciplinary cancer treatment
Lecture 10. Principles of medical cancer treatment
Lecture 11. Cytotoxic Agents
Lecture 12. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines
Lecture 13. Natural Products in Cancer Chemotherapy: Hormones and Related Agents
Lecture 14: Immunotherapy of Cancer
Lecture 15. Clinical decision-making in Oncology
Lecture 16. Evidence building and state of the art on Oncology
Lecture 17. The psychological models in cancer care
Lecture 18. Complications of cancer treatment
Lecture 19. Complications of cancer disease
Lecture 20. Psychological complications of cancer disease
Lecture 21. Principal of communication skills in cancer care
Lecture 22. Lung cancer as a clinical model
Lecture 23. Colorectal cancer as a clinical model
Lecture 24. Breast cancer as a clinical model
Lecture 25. Prostate cancer as a clinical model
Lecture 26. Rare versus frequent cancers
Lecture 27. Head & Neck cancer a multidisciplinary approach
Lecture 28. Unknown primary cancers
Lecture 29. Radiologic evaluation
Lesson 30. Role of Nuclear Medicine: imaging and therapy
Lecture 31. Radiobiology and radioprotection
Lecture 32. Radiotherapy: indications, combinations with other modalities, techniques, side effects (prevention and management)
Lecture 33. Radiotherapy alone and in combination with other modalities for big killers: breast and lung cancers
Lecture 34. Radiotherapy alone and in combination with other modalities for big killers: prostate and GI tumors
Metodi didattici
Lectures will be provided favoring an interactive climate. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Materiale di riferimento
· Harrison's Principles of Internal Medicine, McGraw Hill 19th Edition, chapters: # 3, 4, 10, 15, 17, 18, 91, 99, 100, 101, 102, 103, 104, 120, 121, 122, 125 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Papadakis MA et al Current Medical Diagnosis & Treatment, McGraw Hill chapter on the 2017 Edition: # 9
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
· Slides and scientific material provided during lectures
Radiology and radiotherapy
Programma
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Medical oncology.
Metodi didattici
Lectures will be provided favoring an interactive climate. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Materiale di riferimento
· Harrison's Principles of Internal Medicine, McGraw Hill 19th Edition, chapters: # 3, 4, 10, 15, 17, 18, 91, 99, 100, 101, 102, 103, 104, 120, 121, 122, 125 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Papadakis MA et al Current Medical Diagnosis & Treatment, McGraw Hill chapter on the 2017 Edition: # 9
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
· Slides and scientific material provided during lectures
Pharmacology
Programma
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Medical oncology.
Metodi didattici
Lectures will be provided favoring an interactive climate. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Materiale di riferimento
· Harrison's Principles of Internal Medicine, McGraw Hill 19th Edition, chapters: # 3, 4, 10, 15, 17, 18, 91, 99, 100, 101, 102, 103, 104, 120, 121, 122, 125 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Papadakis MA et al Current Medical Diagnosis & Treatment, McGraw Hill chapter on the 2017 Edition: # 9
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
· Slides and scientific material provided during lectures
General psychology
Programma
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Medical oncology.
Metodi didattici
Lectures will be provided favoring an interactive climate. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Materiale di riferimento
· Harrison's Principles of Internal Medicine, McGraw Hill 19th Edition, chapters: # 3, 4, 10, 15, 17, 18, 91, 99, 100, 101, 102, 103, 104, 120, 121, 122, 125 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Papadakis MA et al Current Medical Diagnosis & Treatment, McGraw Hill chapter on the 2017 Edition: # 9
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
· Slides and scientific material provided during lectures
Pathology
Programma
The course is based on a strong integration of different disciplines, thus the program of the single disciplines cannot be extracted form the program of the whole course which is reported in module Medical oncology.
Metodi didattici
Lectures will be provided favoring an interactive climate. Practical activities will be used, through simulation or in the ward, to consolidate technical and soft knowledge and skills developed during frontal lectures.
Materiale di riferimento
· Harrison's Principles of Internal Medicine, McGraw Hill 19th Edition, chapters: # 3, 4, 10, 15, 17, 18, 91, 99, 100, 101, 102, 103, 104, 120, 121, 122, 125 (also available as ebook in the digital library of the University of Milano http://www.sba.unimi.it/)
· Papadakis MA et al Current Medical Diagnosis & Treatment, McGraw Hill chapter on the 2017 Edition: # 9
· Robbins and Cotran. Pathologic basis of Disease (9th Edition)
· Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
· Slides and scientific material provided during lectures
Moduli o unità didattiche
General psychology
M-PSI/01 - PSICOLOGIA GENERALE - CFU: 1
Lezioni: 12 ore

Medical oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 3
Lezioni: 36 ore

Pathology
MED/08 - ANATOMIA PATOLOGICA - CFU: 1
Lezioni: 12 ore
Docente: Fusco Nicola

Pharmacology
BIO/14 - FARMACOLOGIA - CFU: 1
Lezioni: 12 ore

Radiology and radiotherapy
MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA - CFU: 1
Lezioni: 12 ore

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