Epidemiology, pathogenesis and diagnostics of cancer
A.A. 2020/2021
Obiettivi formativi
The training course aims to transfer to the students the basic knowledge of tumors pathogenesis and diagnosis, with particular reference to the development of the epidemiology, pathology and medical genetics notions and their applications to the diagnosis and therapy of tumors.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
growth
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
growth
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
Risultati apprendimento attesi
Epidemiology of cancer
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors
Periodo: Terzo trimestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Terzo trimestre
All classes planned during the third trimester of the first year of the Master Degree Medical Biotechnology and Molecular Medicine, will be given as frontal teaching and distance synchronous learning. In case of a new suspension of frontal lectures, all students will be asked to move to distance synchronous learning.
Each hour of lesson will be divided into 45' of formal teaching followed by 15' of discussion/interaction/question time. All lessons will be recorded and made available for students on the indicated platforms (i.e. Ariel, TEAMS, etc).
Unless otherwise specified, exams will be organized in classroom but if the student is unable to reach the building for COVID-related issues, other forms will be considered (this apply for exams scheduled until the 31st July - 2021).
Each hour of lesson will be divided into 45' of formal teaching followed by 15' of discussion/interaction/question time. All lessons will be recorded and made available for students on the indicated platforms (i.e. Ariel, TEAMS, etc).
Unless otherwise specified, exams will be organized in classroom but if the student is unable to reach the building for COVID-related issues, other forms will be considered (this apply for exams scheduled until the 31st July - 2021).
Programma
Medical statistics:
Patterns and trends of cancer mortality in Europe.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
General pathology and immunology:
Cancer Stem Cells:
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the
tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature
senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated
secretory phenotype.
Medical Oncology:
Natural history of solid cancer; Cancer clinical methodology; Building state of the art in oncology;
Principles of cancer multidisciplinary treatment; Principles of medical cancer treatment; Biology-driven therapy in solid cancer: the
model of colon cancer; Molecularly targeted therapy: the model of GIST.
Blood diseases:
Molecular and biological mechanisms of acute and chronic myeloid disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Patterns and trends of cancer mortality in Europe.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
General pathology and immunology:
Cancer Stem Cells:
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the
tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature
senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated
secretory phenotype.
Medical Oncology:
Natural history of solid cancer; Cancer clinical methodology; Building state of the art in oncology;
Principles of cancer multidisciplinary treatment; Principles of medical cancer treatment; Biology-driven therapy in solid cancer: the
model of colon cancer; Molecularly targeted therapy: the model of GIST.
Blood diseases:
Molecular and biological mechanisms of acute and chronic myeloid disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Prerequisiti
The student must have acquired the general concepts of the biological and molecular pathogenetic mechanisms of human diseases and the basic laboratory techniques for the study of cellular functions, phenotype and genome.
Metodi didattici
Frontal lessons supported by visual means. Exercises at the diagnostic and research laboratories of the different course modules. These methods will put the student in the best condition to learn the mechanisms of human diseases and the main and current diagnostic techniques.
Materiale di riferimento
Pdf files of presentations. Review article on different topics.
Modalità di verifica dell’apprendimento e criteri di valutazione
The exam will be a written test on the topics listed in the program. In particular, each student will receive a test with 31 closed-ended questions for the duration of one hour and the mark will be expressed in thirtieths. With the help of slides and laboratory tests, each student will be provided with all the tools necessary for passing the exams. The result of the written test will be communicated on the Unimia portal.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore
Docenti:
Carniti Cristiana, Neri Antonino
General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 1
Lezioni: 7 ore
Docente:
Chiaramonte Raffaella
Medical Oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore
Medical statistics
MED/01 - STATISTICA MEDICA - CFU: 1
Lezioni: 7 ore
Docente:
La Vecchia Carlo Vitantonio Battista
Docente/i
Ricevimento:
da concordare appuntamento via email
Fondazione IRCCS Istituto Nazionale Tumori, Milano
Ricevimento:
previo appuntamento
Ospedale San Paolo, via di Rudinì 8, Milano. Blocco C, 7° piano.
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su appuntamento telefonico
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previo appuntamento da concordare via e-mail