Molecular pharmacology and immunology

A.A. 2020/2021
6
Crediti massimi
48
Ore totali
SSD
BIO/14 MED/04
Lingua
Inglese
Obiettivi formativi
The aim of course is to provide an exhaustive background knowledge of the molecular and cellular mechanisms of actions of drugs, and to provide information on the pharmacological modulation of cellular responses, the molecular aspects of receptors, modulation of intracellular signaling and gene expression. Drugs are considered not only for their therapeutic functions but also as tools to investigate biological phenomena. Immunology is a rapid growing field of research in medicine and attracts a lot of attention for its contribution in various diseases such as infection diseases, cancer and auto-immunity. This is an advanced course in the field of immunology, and will go in-depth, at a molecular level.
Risultati apprendimento attesi
By the end of the course students will have built a strong background in the most recent advances in the fields of pharmacology and immunology. In particular, after the corse the student:
- will know the molecular mechanisms of several class of drugs and the molecular mechanisms underlying the function of the immune system in the contexts discussed within the course;
- will be able to apply the acquired principles in order to choose drugs as appropriate tools to explore and study intracellular signaling;
- will know and be able to apply the experimental methodologies to study pharmacological activities and molecular immunology in a research laboratory;
- will be able to apply the acquired principles in order to understand the experimental procedures described in scientific articles and to interpret them critically;
- know the molecular mechanisms underlying the function of the immune system in the contexts discussed within the course;
- be able to apply the acquired principles in order to understand the experimental procedures described in scientific articles and to interpret them critically;
- Know and be able to apply the experimental methodologies to study molecular immunology in a research laboratory.
Programma e organizzazione didattica

Edizione unica

Periodo
Primo semestre
PHARMACOLOGY :The lessons will be asynchronous, with commented power points uploaded weekly in the Ariel site.
Once a weeks, (Thursday) there will be a a 1 hour synchronous lesson in the TEAMS platform, in order to give explanations.
The criteria to participate in the synchronous lessons will be presented in Ariel.

IMMUNOLOGY:
The lessons will be in mixed modality (synchronous/asynchronous) , to be coordinated with students. The MS TEAMS platform and the Ariel site will be used for communication with the students. Articles will aslo be presented, to be prepared with the students
Programma
Students will encounter the following topics in the pharmacology and immunology fields:
Molecular Pharmacology and molecular immunology
Pharmacogenetics
The pharmacology of signal transduction.
Kinase inhibitors as antitumor drugs.
Monoclonal antibodies and soluble receptors as drugs
Transporters as drug targets
The pharmacology of post translational modifications
Immunosuppressants and immunostimulants
The endocannabinoid system
Excitatory amino acids and excitotoxicity
The physiopathology of pain and analgesics
G protein receptor regulation
Chemotherapy of microbial diseases and drug resistance
Chemotherapy of neoplastic diseases
Vaccinations
Allergic diseases
Autoimmune diseases
Microbiota and the immune system
Cancer Immunotherapy
Immunodeficiencies (AIDS and Kaposi sarcoma).
Prerequisiti
Basic knowledge of anatomy and human physiology.
Metodi didattici
PHARMACOLOGY: Power point with comments uploaded in ARIEL.
1 hour/week meeting with TEAMS for explanation
IMMUNOLOGY:Power point presentations with audio or lessons, article prepared and presented with the students.
Materiale di riferimento
Cellular and Molecular Immunology (AK Abbas e AH Lichtman, Elsevier, 2017
Basic and clinical pharmacology (Katzung, Piccin).
Scientific papers and articles cited during the courses will be made available through the course Ariel website.
Modalità di verifica dell’apprendimento e criteri di valutazione
PHARMACOLOGY: The exams will be oral on the program explained during the course on TEAMS platform. The exam will check the knowledge of the different topics, the ability of the student to make connections and to use an adequate scientific language.

Immunology: The exams will be oral on the program explained during the course on TEAMS platform. The exam will check the knowledge of the different topics, the ability of the student to make connections and to use an adequate scientific language. Preparation and idscussion of articles by the students during the course will also be considered as part of the evaluation.

The final mark will be the average of pharmacology and Immunology marks.
BIO/14 - FARMACOLOGIA - CFU: 0
MED/04 - PATOLOGIA GENERALE - CFU: 0
Lezioni: 48 ore
Docente/i
Ricevimento:
Previo appuntamento via e-mail
Ricevimento:
lunedì, 14.30-16.30; giovedì,14.30-15.30
via Vanvitelli 32