"Advanced peptide engineering" unit: -introduction to nanomaterials: definition, types and applications; - main analytical techniques (UV/VIS, Fluorescence, DLS, TEM, SEM, AFM); - synthesis and characterization of inorganic nanomaterials (gold, silver, iron, ceramic), bioinspired nanomaterials (peptides, proteins), hybrid peptide functionalized nanomaterials (metal-organic frameworks, liposomes and polymeric);
"Nanovectors and drug targeting" unit: - modified release dosage forms and disperse systems; - colloidal systems; - nanovectors used for drug delivery (nanocrystals, nanoparticles, lipid vesicles); -preparation, characterization and sterilization methods of nanovectors; - nanovectors for advanced therapy and vaccination.; -regulatory aspects about the production and marketing authorization of nanotechnology based products.
"Safety and toxicology of nanoparticles" unit: -introduction to nanotoxicology; - safety and toxicological aspects of inorganic, organics, hybrids and bioinspired nanomaterials; - risk assessment of nanomaterials; in vivo and in vitro evaluation of nanomaterials toxicity.
Advanced peptide engineering" unit: Basic knowledge of inorganic and organic chemistry (atomic structures, types of bonds and molecular interactions, definition of metal, concepts of acidity and basicity, electromagnetic spectrum, the main organic functional groups and their reactivity).
"Nanovectors and drug targeting" unit: Basic knowledge of physics, chemistry, biology and pharmaceutical technology. Students should be familiar with the concepts of medicinal products, dosage forms and administration routes. They should have also a basic knowledge of the Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy
"Safety and toxicology of nanoparticles" unit: Basic toxicology knowledge (ADI, principles of organ toxicity, in vivo and in vitro toxicity tests, risk assessment).
Materiale di riferimento
D. Ruiz-Molina, F. Novio, C. Roscini. Bio- and Bioinspired nanomaterials. Wiley
S. Perret, A.K. Buell, T.P.J. Knowles Biological and bioinspired nanomaterials. Springer
S. Rajendran, A. Mukherjen, T.A. Nguyen, C. Godugu, R.K. Shukla Nanotoxicity, Elsevier
B. Fadel, A. Pietroiusti, A.A. Shvedova Engineered nanomaterials, Elsevier
Slides of the lessons.