Pharmacogenetics and epigenetics in toxicology

A.A. 2021/2022
Crediti massimi
Ore totali
Obiettivi formativi
The course aims to provide the basic knowledge to understand the genetic basis of the differences in metabolic processes that influence individual responses to xenobiotic.
Furthermore, it will set the theoretical basis for understanding how these individual responses might be influenced by the epigenoma.
The concepts of genetic and epigenetic mutations will be developed to understand how these mutations contribute to the inter-individual susceptibility to xenobiotic. The course will also provides the principles of pharmacogenetics and pharmacogenomics with the goal to show when and how the genetic factors, defined at different levels from chromosomes to single nucleotide, plays a role in the variability of Mendelian and complex diseases, and in the variability of drug-response.
Risultati apprendimento attesi
At the end of the course the student will know the basics of the genetic and epigenetic processes that regulate the physiological mechanisms in living organisms and how xenobiotics are able to interfere with these processes by altering the cellular phenotype; students will also be provided with the basics of the main methods and laboratory techniques useful for evaluating genetic and epigenetic modifications. At the end of the course the student will have acquired the necessary knowledge to evaluate the complexity of the interaction between xenobiotics and higher organisms as a result of processes, interconnected with each other, that occur at the molecular, genetic and epigenetic level. Students will also be able to critically review the scientific literature devoted to the genetic and epigenetic aspects of the exposure of organisms above xenobiotics.
Programma e organizzazione didattica

Edizione unica

Secondo semestre
More specific information on the delivery modes of training activities for academic year 2021/22 will be provided over the coming months, based on the evolution of the public health situation
- The genetic: historical perspectives and general concepts
- Basic principles of epigenetic biology
- Epigenetic, genetic and environment in CNS diseases
- Genetic and environment in CVD diseases
- Technologies for genomics and epigenomics studies
- Pharmacological modulation of epigenetics
- Genetic polymorphism in xenobiotic metabolism
- Environmental epigenetics- part 1
- Environmental epigenetics- part 2
- Pharmacogenetics and pharmacogenomics
- Pharmacogenetics and pharmacogenomics in toxicology
- Overview of the course and conclusion
No prior knowledge is required except the rudiments of toxicology and cell biology learned in training activities in the same course of study.
Metodi didattici
The course is divided into a series of front lessons with slide projection in Power Point. The lectures slides are loaded on the Ariel website. In addition to the teacher of reference, interventions of experts on specific topics will be also possible.
Materiale di riferimento
Articles and reviews on the topics covered in the course will be made available from the Ariel website.
Modalità di verifica dell’apprendimento e criteri di valutazione
The final assessment of the knowledge learned and the skills developed during the course takes place through the final exam which consists of an interview of about an hour. The exam is considered passed if the student has achieved a minimum score of 18 points in the written test.
The booking on the UNIMIA portal, within the dates established for each appeal, is mandatory for the examination
Lectures: 48 ore
Docente: Sironi Luigi