Morphological and molecular basis of the central nervous system and its pathologies
A.A. 2023/2024
Obiettivi formativi
The course aims to provide an understanding of aspects related to the two main integrative systems of the body, the nervous and endocrine systems. Anatomy, function and hormonal regulation of Central and Peripheral Nervous System is covered with developmental anatomy added when applicable.
The course will also provide information about pathogenesis of the most important neurological diseases, and on the animal models that are used for their study and comprehension.
The course will also provide information about pathogenesis of the most important neurological diseases, and on the animal models that are used for their study and comprehension.
Risultati apprendimento attesi
At the end of the Course the student acquires:
Knowledge and understanding of the the nervous and of the endocrine systems, with specific reference to their anatomy, their function and interactions/regulations as well as well as their pathological alterations.
Ability to apply knowledge and understanding in critically read the literature and textbooks and use an improved communication skill with scientific terminology.
Knowledge and understanding of the the nervous and of the endocrine systems, with specific reference to their anatomy, their function and interactions/regulations as well as well as their pathological alterations.
Ability to apply knowledge and understanding in critically read the literature and textbooks and use an improved communication skill with scientific terminology.
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento può essere seguito come corso singolo.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Secondo semestre
Programma
Lectures
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)
Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)
Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Prerequisiti
Basic knowledge of histology and anatomy
Metodi didattici
lectures and practices
Materiale di riferimento
Handouts
Modalità di verifica dell’apprendimento e criteri di valutazione
written exam
VET/01 - ANATOMIA DEGLI ANIMALI DOMESTICI - CFU: 5
VET/03 - PATOLOGIA GENERALE E ANATOMIA PATOLOGICA VETERINARIA - CFU: 3
VET/03 - PATOLOGIA GENERALE E ANATOMIA PATOLOGICA VETERINARIA - CFU: 3
Esercitazioni: 24 ore
Lezioni: 36 ore
Lezioni: 36 ore
Docente/i
Ricevimento:
tutti i giorni previo appuntamento
Ricevimento:
Da concordare via mail
Dipartimento di Medicina Veterinaria e Scienze Animali- Stanza 172
Ricevimento:
Tutti i giorni su appuntamento
Via Dell'Università 6 - Lodi; Via Trentacoste 2 - Milano