Cellular and molecular pharmacology

A.Y. 2018/2019
Overall hours
Learning objectives
The objective of this course is to provide knowledge on: i) the path leading to drug development (basic research, pre-clinical trials and clinical studies); ii) molecular and cellular mechanisms underlying drugs activity; iii) pharmacogenetics and pharmacogenomics; iv) gene therapy; v) new molecular medications (RNA drugs); vi) role of stem cells in drug discovery and therapy.
Expected learning outcomes
Course syllabus and organization

Single session

Course syllabus
Drug development. R&D from the Nineties to present. Rational approach to drug design. Molecular modelling. Hit identification. Lead optimisation and development of medications. Preclinical development of medications and clinical studies. GMP production.

Receptors, signal transduction and receptor classes. Modulation of receptor responses. Channel receptors, G-protein coupled receptors, growth factor receptors and cytokines. Intracellular calcium homeostasis. Pharmacological modulation of post-translational modifications.

Proteolysis. Mechanisms and pharmacology of intra-and extra-cellular proteolysis.

Intercellular communication. Pharmacological regulation of synaptic function. Pharmacology of neurosecretion. Pharmacological modulation of excitatory and inhibitory synaptic transmission.

Pharmacology of gene transcription. Epigenetic drugs. RNA Drugs: Mechanisms of action, administration, chemical structure and toxicology.

Pharmacogenetics and Pharmacogenomics. The genome project and its relevance to drug development. Genomic medicine, precision Medicine, personalized medicine.

Gene therapy. Vectors and strategies of gene transfer. Gene therapy for monogenic diseases, diabetes, cancer and cardiovascular system.

Stem cells in drug development and discovery. Stem cells therapies.

Ppt presentation and videos

Reference Material
Scientific articles and reviews

Prerequisites and examination procedures
Oral examination

Teaching Methods
Traditional frontal lesson

Language of instruction

Recommended Prerequisites

Program information
Ppt files and scientific articles will be available on Ariel 2.0 WebSite
BIO/14 - PHARMACOLOGY - University credits: 6
Lessons: 48 hours
Professor: Zuccato Chiara
by appointment previously agreed by e-mail
INGM, Padiglione Invernizzi, Via F. Sforza 35 4 piano Ala A