Experimental immunology and immunobiotechnology
A.Y. 2018/2019
Learning objectives
The course aims at providing a general understanding of potentials and limitations of experimental immunology approaches to the understanding on molecular and cellular mechanisms underlying human immunopathology, here developed approaching a selection of immunological diseases as cases of study.
Expected learning outcomes
The students will learn how to investigate on the pathogenesis of models of human diseases starting from the unanswered clinical and biological questions. The knowledge of the advanced biotechnologies and of animal models will make it possible to understand what technical tools and approaches are currently available to disclose the cellular and molecular mechanisms of human diseases.
Lesson period: Third trimester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Third trimester
General pathology and immunology
Course syllabus
Potential and Limitations of modern biotechnologies to be used to investigate on the pathogenesis of the above-mentioned autoimmune diseases (Flow Cytometry - Omics - Gene Therapies - Approaches of Translational Medicine).
Reumatology
Course syllabus
Lessons introducing the current knowledge in regard to the physiopathology of the following auto-immune diseases:
a) Systemic Lupus Erythematosus (SLE);
b) Antiphospholipid Syndrome (APS);
c) Systemic Sclerosis (SSc);
d) Vasculitis. (Cellular and molecular mechanisms - Biomarkers and autoantibodies - Novel therapeutic approaches - Transplant in autoimmunity - Biological Therapies).
a) Systemic Lupus Erythematosus (SLE);
b) Antiphospholipid Syndrome (APS);
c) Systemic Sclerosis (SSc);
d) Vasculitis. (Cellular and molecular mechanisms - Biomarkers and autoantibodies - Novel therapeutic approaches - Transplant in autoimmunity - Biological Therapies).
Laboratory medicine
Course syllabus
Each student will be asked to focus on a specific aspect related to experimental immunology and immunobiotechnology implications for each defined theme working on a selection of research articles indicated by the Faculty. This step will be developed in a series of meetings with the tutor.
Domestic animal infectious diseases
Course syllabus
Potential and Limitations of the murine models associated to the above-mentioned autoimmune disorders (Production and analysis of transgenic animals - Gene targeting technologies - Production and analysis of knock out animals - Conditional gene targeting - In vivo experiment planning - Legislation - Models of experimental pathology in autoimmunity and transplantation - Production and analysis of bone marrow chimeras - Xenografts and humanized mice).
Domestic animal infectious diseases
VET/05 - INFECTIOUS DISEASES OF DOMESTIC ANIMALS - University credits: 2
Lessons: 14 hours
Professor:
Riva Federica
General pathology and immunology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 1
Lessons: 7 hours
Professor:
Locati Massimo
Laboratory medicine
MED/46 - BIOTECHNOLOGY AND METHODS IN LABORATORY MEDICINE - University credits: 2
Lessons: 14 hours
Professor:
Mavilio Domenico
Reumatology
MED/16 - RHEUMATOLOGY - University credits: 1
Lessons: 7 hours
Professor:
Selmi Carlo Francesco
Professor(s)
Reception:
On Appointment
Istituto Clinico Humanitas, Via A. ;anzoni 113, Rozzano, Milano