Cardiovascular Research

A.Y. 2019/2020
4
Max ECTS
40
Overall hours
SSD
MED/02 MED/23 SECS-S/02
Language
Italian
Learning objectives
- To acquire the principles of statistics applied to experimental and technological research
- To acquire epidemiological and statistical methods and tools
- To learn the scientific progress of medical art and the evolution of medical thought over time
Expected learning outcomes
- Ability to read and critically prepare scientific publications
- Acquisition of skills to plan and carry out research applied to the field of technical health disciplines
Course syllabus and organization

Single session

Prerequisites for admission
No previous knowledge is required
Assessment methods and Criteria
The profit test will be written. It will mainly consist of multiple-choice questions with the addition of a few open questions; in addition it will be possible, at the teacher's discretion, to take an additional oral test. The profit test consists of an interview on all the topics covered in the course, aimed at ascertaining that the student is able to understand, describe and recognize as well as having good knowledge of the evolution of the thought, techniques and instruments used in Medicine and Surgery, to understand the birth and evolution of Cardiovascular Pathophysiology and Cardiovascular Perfusion with an eye to research and clinical trials
Storia della medicina
Course syllabus
Origins and significance of Medicine and History of Medicine; Medicine in Rome, Medieval Medicine; Renaissance: systematic anatomy, animated anatomy, microscopic anatomy, iatrochemistry and iatromechanics.
Enlightenment and public health; The birth of the clinic and its instruments (semeiotics, diagnostics and therapy); The problems of surgery and their resolution: analgesia, anesthesia, asepsis and antisepsis. XX century: new concepts, instruments and therapies; History of cardiology and cardio-thoracic surgery. The first heart-lung machine. Historical research in the cardiovascular field.
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Bock G, Quaderno di Storia della Medicina e della Chirurgia, Rudiano (BS), GAM Editrice, 2004
Gibbon JH, An Oxygenator with a large surface volume ratio. Journal of Laboratory and Clinical Medicine 1939; 24: 1192-1198
Lim MW, The History of extracorporeal Oxygenators. Anaesthesia 2006; 61: 984-995
Modelli sperimentali di ricerca cardiovascolare
Course syllabus
The concept of model and model organism
Models for in vitro cardiovascular research (heart cells and other cell lines)
Usable infection, infection and vectors
Gene silencing
In vivo cardiovascular research models (mouse models) Generation of a transgenic organism Conventional and conditional model (Cre-LoxP) Models for the study of atherosclerosis (e.g. ApoE - / -) Models for the study of heart attack (surgical model) Models for the study of hypertension (mouse surgical models and specific strains, e.g. SHR) Evidence-based medicine Primary clinical research: observational and experimental studies Secondary clinical research: meta-analysis and systematic reviews The phases of the clinical trial Planning and conducting a clinical trial
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Manuela Cassotta, Valentina Marchi - LE NUOVE FRONTIERE DELLA SCIENZA. MODELLI SPERIMENTALI PER LA RICERCA BIOMEDICA DEL XXI SECOLO - Libreria Studio Bosazzi
Libreria AbeBooks
Statistica per la ricerca sperimentale e tecnologica
Course syllabus
Statistical variables, their summary measures and graphical representations Contingency tables and the concept of conditional frequency The normalized normal and normal distribution and their properties
Introduction to randomized clinical trials The logic of randomization Blindness The choice of the control arm The ethicality of the studies Method for critical reading of a randomized study
The interpretation of the confidence interval and statistical significance of the main association measures.
Relative risk, differences between risks and hazard ratios
Reading and interpretation of survival curves Interpretation and logic of systematic reviews and meta-analysis The concept of weighted average The methods for the combination of results The heterogeneity The forrest plot
Studies of diagnostic accuracy
The concepts of: sensitivity, specificity, positive and negative predictive value
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
.B.Lantieri, D. Risso, G. Ravera. ELEMENTI DI STATISTICA MEDICA McGraw-Hill Libri Italia srl
Modelli sperimentali di ricerca cardiovascolare
MED/23 - HEART SURGERY - University credits: 1
Lessons: 10 hours
Professor: Pompilio Giulio
Statistica per la ricerca sperimentale e tecnologica
SECS-S/02 - STATISTICS FOR EXPERIMENTAL AND TECHNOLOGICAL RESEARCH - University credits: 2
Lessons: 20 hours
Storia della medicina
MED/02 - MEDICAL HISTORY - University credits: 1
Lessons: 10 hours