Clinical Pathology and Pharmacology

A.Y. 2019/2020
5
Max ECTS
50
Overall hours
SSD
BIO/14 MED/05 MED/09 MED/18
Language
Italian
Learning objectives
- Acquisition of the principles of pharmacodynamics, pharmacokinetics and the main pharmacological interactions
- To acquire notions of relevant pathologies in the field of medicine and their therapeutic approach
- To acquire notions of relevant pathologies in the surgical field and their therapeutic approach
- Knowledge of laboratory diagnostics
Expected learning outcomes
- To now the mechanisms of action and the side effects of the main classes of drugs
- Interpretation of laboratory data in relation to the values obtained
- In-depth knowledge of diseases related to the cardiovascular system in the medical and surgical field
Course syllabus and organization

Single session

Responsible
Prerequisites for admission
No prior knowledge is required
Assessment methods and Criteria
The exam will be written. It will mainly consist of multiple choice questions with the addition of some open questions, in addition it will be possible, at the discretion of the teacher, to carry out an additional oral test.
Farmacologia
Course syllabus
Meaning and purpose of pharmacology. Routes of administration of the drugs. Absorption, distribution, biotransformation and excretion of drugs. (General principles of pharmacology. Drug absorption, biovailability, and routes of administration. Distribution of drugs. Metabolism and excretion of drugs.)
General concepts of pharmacokinetics. (Clinical pharmacokinetics)
Pharmacodynamics: receptors, drug / receptor interaction, endocellular transduction mechanisms of the receptor response (Pharmacodynamics: drug receptors, mechanisms of drug action and the relationship between drug concentration and effect).
General functions of the autonomic and somatic motor nervous system
Drugs and Cholinergic Systems: muscarinic receptor agonists and antagonists. Substances with anticholinesterase activity. Drugs that act on the neuromuscular junction and autonomic ganglia (Acetylcholine and its muscarinic receptor target: muscarinic receptor agonists and antagonists. Anticholinesterase agents. Neuromuscular blocking agents)
Drugs acting on the Sympathetic Nervous System: adrenergic agonists and antagonists. Drugs that act on the synthesis, degradation and uptake of catecholamines (Adrenergic agonists and antagonists Indirect acting sympathomimetic drugs).
Serotonin and dopamine (Serotonin and dopamine)
General principles of antimicrobial theraphy
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Richard D.Howland e Mary J. Mycek, Le basi della Farmacologia Zanichelli editore
Patologia clinica
Course syllabus
General: definition and meaning of molecular biomarker, use of laboratory tests (diagnosis, prognosis, monitoring, screening). Accuracy accuracy, sensitivity and specificity. Laboratory data interpretation: Normal values and reference limits. Causes of variability. Patient preparation, collection and storage and rules for the transport of biological fluids (blood, urine, feces and others). Urinalysis and its clinical significance. Kidney function: clearance. Blood test and meaning of the different concentration of the different blood cells. Notes on anemias and main blood diseases. Myocardial damage biomarkers Clinical enzymology: measurement of enzymatic activity. Alkaline phosphatase, acid phosphatase, transaminase, gamma GT, amylase, CPK, LDH Plasma proteins: methods of determination. Classes and functions. Cardiometabolic biomarkers Blood lipoproteins: classes and functions. Blood and urine glucose determination. Diabetes: diagnosis and monitoring. Liver: clinical significance of bilirubin and liver enzymes
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Manuale di diagnostica di laboratorio, M. Cioffi e Coll., Edizioni Minerva Medica, ed. anno 2010 Sanitaria - Piccin Editore
Medicina interna
Course syllabus
Diabetes Cardiovascular pathologies
Ischemic heart disease
Cardiovascular failure Atherosclerosis
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Harrison (Kasper Braunwal, Fauci, Hauser, Longo Jameson) - Principi di Medicina Interna - McGraw-Hill
Massini, Longhi, Marghetti - Medicina interna - McGraw-Hill
Chirurgia generale
Course syllabus
The infections in surgery
Shock (hypodynamic and hyperdynamic forms)
Pneumothorax
Clinic and surgical pathology of esophagus and stomach
Clinical and surgical pathology of colon, rectum and anus
Clinical and surgical pathology of liver, pancreas and biliary tract
Clinic and surgical pathology of kidney and urinary tract
Teaching methods
The courses will include lectures with the possible addition of laboratory exercises
Teaching Resources
Dionigi: CHIRURGIA - Basi teoriche e Chirurgia generale - Masson (IVa ed.)
Sabiston: Trattato di chirurgia - Delfino editore
Chirurgia generale
MED/18 - GENERAL SURGERY - University credits: 1
Lessons: 10 hours
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 2
Lessons: 20 hours
Professor: Sibilia Valeria
Medicina interna
MED/09 - INTERNAL MEDICINE - University credits: 1
Lessons: 10 hours
Professor: Bolla Giovanni Battista
Patologia clinica
MED/05 - CLINICAL PATHOLOGY - University credits: 1
Lessons: 10 hours
Professor: Magni Paolo
Educational website(s)
Professor(s)
Reception:
by appointment
Department of Pharmacological and Biomolecular Sciences