Medical Sciences

A.Y. 2019/2020
4
Max ECTS
40
Overall hours
SSD
BIO/14 MED/03 MED/04 MED/08
Language
Italian
Learning objectives
The learning objectives of the Medical Sciences course are:
- to know the genetic and biological mechanisms;
- to know the main pathological mechanisms;
- to know the main anatomical and histological alterations;
- to know the principles of pharmacology.
Expected learning outcomes
At the end of the course the student will have to know the genetic and biological mechanisms and their alterations, to know the etiopathogenetic factors underlying the structural and functional alterations involved in human pathology, and to know the principles of pharmacology.
Course syllabus and organization

Single session

Prerequisites for admission
There are no specific prerequisites different from those required for admission to the degree course
Assessment methods and Criteria
The final exam will take place through a written test with multiple choice questions. The duration of the scheduled test is 1 hour maximum for each module.
The evaluation criteria will be the ability to understand the topics addressed during class lessons.
The final mark will be obtained by the average of the marks acquired in each course module and will be expressed by using 30/30 scale. No intermediate tests are foreseen. The results of the exam will be communicated to the students online by the secretary of the degree course.
Farmacologia
Course syllabus
1. Drug interactions
2. Effect of agonist and antagonist drugs
3. Pharmacokinetics absorption and distribution of drugs
4. Pharmacokinetics metabolism and elimination of drugs
5. Pharmacovigilance
6. Pharmacogenetics
Teaching methods
Lectures
Teaching Resources
AA VV Farmacologia generale e molecolare a cura di F. Clementi e G Fumagalli, editore Edra SpA
Genetica medica
Course syllabus
Cell division: mitosis, meiosis and their differences. The crossing over. Chromosomes: structure, karyotype, chromosome banding, inactivation of the X chromosome. Chromosomal basis of inheritance: chromosomal anomalies in number and structure. Methods for identifying chromosomal abnormalities. DNA mutations: the different categories of DNA mutations. Methods for finding mutations. Mendelian inheritance: autosomal dominant inheritance, autosomal recessive inheritance, inheritance linked to the X chromosome. Family trees: definition, construction and study of family trees. Interpretation issues: variable expressivity, incomplete penetrance, genetic heterogeneity, late-onset diseases, anticipation, germinal mosaicism. Genetic imprinting, triplet expansion diseases, mitochondrial diseases. Complex diseases: polygenic and multifactorial characters. Genetics of deafness: syndromic and non-syndromic forms. Genetics of speech disorders: examples of genetic pathologies and genomic disorders
Teaching methods
Lectures
Teaching Resources
Neri e Genuardi - Genetica Umana e Medica Quarta ed. [Edra Masson]
Dispense a cura del docente.
Patologia generale
Course syllabus
· Homeostasis. Health and disease. Etiology and pathogenesis.
· Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
· Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
· Cell death: necrosis and apoptosis.
· Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
· Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
· Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
· Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia. Laryngeal carcinoma.
Teaching methods
Lectures
Teaching Resources
G.M. Pontieri. PATOLOGIA GENERALE E FISIOPATOLOGIA GENERALE. Piccin
J. Maier. PATOLOGIA GENERALE E FISIOPATOLOGIA. Mc GrawHill
Anatomia patologica
Course syllabus
· Concepts of hyperplasia, hypertrophy, cellular atypia, dysplasia, neoplasia.
· concept and meaning of carcinoma in situ and invasive carcinoma
· grading and staging of malignancies (TNM)
· pathology of the larynx (congenital malformations; polyps and laryngeal nodules, laryngitis; squamous cell carcinoma)
· oral pathology: a) malformative (micrognathia; labiopalatoschisis; macroglossia) b) non-neoplastic pathology (ulcerated lesions of the oral cavity; leukoplakia; candidiasis; herpetic lesions) c) oral pathology in the course of AIDS: warty leukoplakia and Kaposi's sarcoma. d) squamous cell carcinoma of the oral cavity, e) precancerous lesions and conditions, f) rare tumors oF the oral cavity: lymphomas, melanoma and rhabdomyosarcoma, g) odontogenic cysts and odontogenic tumors
· pathology of the salivary glands: outline of the anatomy and histology of the major and minor salivary glands; mumps; s.diSjogren; tumors (pleomorphic adenoma, T. warthin, adenoid cystic carcinoma, mucoepidermoid carcinoma)
· pathology of the pharynx and upper respiratory tract. Background.
· neck cyst (thyroglossal duct cyst)
· ear pathology: osteoma and cholesteatoma
· ear pathology
Teaching methods
Lectures
Teaching Resources
Robbins - Cotran - Kumar - Klatt - AAVV- ANATOMIA PATOLOGICA
Anatomia patologica
MED/08 - PATHOLOGY - University credits: 1
Lessons: 10 hours
Professor: Nebuloni Manuela
Farmacologia
BIO/14 - PHARMACOLOGY - University credits: 1
Lessons: 10 hours
Professor: Carnovale Carla
Genetica medica
MED/03 - MEDICAL GENETICS - University credits: 1
Lessons: 10 hours
Professor: Crippa Milena
Patologia generale
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 1
Lessons: 10 hours