Molecular Genetics and Epigenetics of the Cell
A.Y. 2019/2020
Learning objectives
- Acquisition of up-to-date fundamental knowledge in the control of gene expression through lectures and discussion sessions.
- Analysis of scientific papers
- Introduction to bioinformatics tools with a series of tutorials to analyze genomic databases, with a specific application to the analysis of genome evolution.
- Analysis of scientific papers
- Introduction to bioinformatics tools with a series of tutorials to analyze genomic databases, with a specific application to the analysis of genome evolution.
Expected learning outcomes
Undefined
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Lesson period
First semester
Course syllabus
Goals:
- Acquisition of up-to-date fundamental knowledge in the control of gene expression through lectures and discussion sessions.
- Analysis of scientific papers
- Introduction to bioinformatics tools with a series of tutorials to analyze genomic databases, with a specific application to the analysis of genome evolution
Program:
This course offers a general view of the new advances related to the control of gene expression, genome structure and organization across the tree of life: bacteria, lower (yeast-, protozoan-) and higher (plant-, mammalian-) eukaryotes, and viruses.
It focuses on the analysis and understanding of the mechanisms underlying gene expression. This includes in vitro and in vivo approaches as well as the newest developments in gene editing.
A specific emphasis will be given to new aspects of gene regulation at a transcriptional and post-transcriptional level in eukaryotic cells (animals and plants). In particular, the role of the epigenome involving DNA methylation, histones and histone variants, long and short non-coding RNAs will be illustrated.
The questions that are addressed in the fields of evolution, cell differentiation and development will be presented through a broad range of model organisms (human, mouse, plants, yeast, bacteria ). The mechanisms used by parasites and viruses to infect host cells will be analyzed as well.
Through these different models, we will see that although specificities exist in the control of gene expression and the way organisms adapt to their environment, common mechanisms and common themes do exist throughout the tree of life.
Key words: Transcriptional and post-transcriptional gene expression regulation, chromosome structure, RNA interference, gene editing, genomes evolution and adaptation, infection, non-coding genomes, genetics and epigenetics.
Prerequisites and examination procedures:
Prerequisites
Cell biology, Biochemistry
Examination procedures
· Mid-term exam: Oral (1:30h, 20%) + Genomics and Transcription analysis (6:00h, 20%)
· Final exam: written exam (2:00h 60%)
Teaching Methods:
Lectures (31.5 hours), Tutorials and discussions (12 hours), Lab sessions (6 hours)
Language of instruction:
English
WEB pages:
https://master-biologie.univ-grenoble-alpes.fr/majors/planta-international-plant-int-/
- Acquisition of up-to-date fundamental knowledge in the control of gene expression through lectures and discussion sessions.
- Analysis of scientific papers
- Introduction to bioinformatics tools with a series of tutorials to analyze genomic databases, with a specific application to the analysis of genome evolution
Program:
This course offers a general view of the new advances related to the control of gene expression, genome structure and organization across the tree of life: bacteria, lower (yeast-, protozoan-) and higher (plant-, mammalian-) eukaryotes, and viruses.
It focuses on the analysis and understanding of the mechanisms underlying gene expression. This includes in vitro and in vivo approaches as well as the newest developments in gene editing.
A specific emphasis will be given to new aspects of gene regulation at a transcriptional and post-transcriptional level in eukaryotic cells (animals and plants). In particular, the role of the epigenome involving DNA methylation, histones and histone variants, long and short non-coding RNAs will be illustrated.
The questions that are addressed in the fields of evolution, cell differentiation and development will be presented through a broad range of model organisms (human, mouse, plants, yeast, bacteria ). The mechanisms used by parasites and viruses to infect host cells will be analyzed as well.
Through these different models, we will see that although specificities exist in the control of gene expression and the way organisms adapt to their environment, common mechanisms and common themes do exist throughout the tree of life.
Key words: Transcriptional and post-transcriptional gene expression regulation, chromosome structure, RNA interference, gene editing, genomes evolution and adaptation, infection, non-coding genomes, genetics and epigenetics.
Prerequisites and examination procedures:
Prerequisites
Cell biology, Biochemistry
Examination procedures
· Mid-term exam: Oral (1:30h, 20%) + Genomics and Transcription analysis (6:00h, 20%)
· Final exam: written exam (2:00h 60%)
Teaching Methods:
Lectures (31.5 hours), Tutorials and discussions (12 hours), Lab sessions (6 hours)
Language of instruction:
English
WEB pages:
https://master-biologie.univ-grenoble-alpes.fr/majors/planta-international-plant-int-/
BIO/18 - GENETICS - University credits: 6
Lectures: 48 hours
Professors:
Boussouar FayÇal, Vourc'h Claire
Shifts:
-
Professors:
Boussouar FayÇal, Vourc'h Claire