The course will introduce the basics of Organic Chemistry necessary to obtain a full understanding of the chemical basis of biological molecules and their interactions.
Expected learning outcomes
At the end of this class , the students are expected to be able to understand the chemical basis of the structures and interactions of biological molecules (DNA, RNA, proteins) that will be the main subject of study of the other courses of the degree, and to be able to apply the knowledge acquired to the interpretation of the results of the bioinformatic analysis of biomolecular data.
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
Fundamentals of general chemistry. Chemical bonding and atom hybridization. Lewis structures. Electronegativity and bond polarity. Polarity of molecules. Acids and bases. Introduction to organic molecules and functional groups. Functional groups. Intermolecular forces. Physical properties. Biomolecules. Alkanes and cycloalkanes. Structure, isomerism and nomenclature. Conformational analysis of linear and cyclic alkanes. Stereochemistry. Chirality and stereogenicity. Enantiomers and diastereoisomers. Racemic mixtures and optical rotation. Stereochemical descriptors. Alkyl halides. Nucleophilic substitutions. Elimination reactions. Alkenes. Structure and properties. Allylic systems. Conjugation, resonance and dienes. Lipids. Aromatic compounds. Structure and properties. Alcohols, ethers and related compounds. Structure and properties. Hydrogen bonds and acid properties of alcohols. Oxidation and dehydration. Amines. Structure and properties. Amines as bases. Carbonyl compounds. Structure and properties. Reversible and irreversible nucleophilic addition. Keto-enol tautomerism. Carbohydrates. Structure and properties. Acyclic and cyclic forms of monosaccharides. Glycosides and disaccharides. Carboxylic acids and their derivatives. Structure and properties. Nucleophilic acyl substitution. Acid and basic hydrolysis of esters and amides. Phosphoric acid esters. Amino acids. Structure, properties and classification based on side chains. Acid properties and isoelectric point. Peptide bonds. Enolates of carbonyl compounds. Acidity of the -carbon and substitution reactions of carbonyl compounds. Carbonyl condensation reactions. Structure and properties of -diketones, -ketoesters and -diesters. Malonic and acetoacetic synthesis, biosynthesis of fatty acids. Heteroaromatic compounds. Structure and properties of pyridine, pyrrole, indole, imidazole. Nucleic bases: tautomeric structures and hydrogen bond formation. Structure of nucleosides and nucleotides.
Prerequisites for admission
No prerequisites different from those required for admission to the Master Degree program.
Slides and notes of the classes will be shared with students.