Organic chemistry lab

A.Y. 2019/2020
10
Max ECTS
144
Overall hours
SSD
CHIM/06
Language
Italian
Learning objectives
The aim of the present course is to introduce the student to the main experimental procedures in Organic Chemistry. In order to pursue this goal, the experimental work will be developed individually by each student. Particular care will be devoted to safety rules. The student will learn the main techniques for the isolation and purification of organic compounds. The student will be also introduced to some basic organic reactions, and will learn some procedures for the characterization of the obtained compounds.
Expected learning outcomes
The student will be able to: carry out the routine operations in an organic chemistry lab, paying special attention to the safety aspects (filtration, phase separation, crude reaction mixture isolation, acidic and basic work up, TLC analysis, purification through crystallization, distillation or column chromatography); make adeguate choices with regard to reaction conditions; apply some spectroscopic techniques to solve structural problems for simple organic compounds.
Course syllabus and organization

Single session

Responsible
Course syllabus
Module 1 (5 cfu)
1. Safety and accident prevention in the chemical laboratory
2. Main techniques for the isolation and purification of organic compounds (extraction, crystallisation, simple and fractional distillation, chromatography)
3. Introduction to IR spectroscopy
4. Experimental aspects of some fundamental organic reactions (oxidations, reductions, condensations, nucleophilic substitutions, Fischer synthesis), evaluation of the purity grade of the obtained products through TLC and melting point measurement
5. The experimental activities performed in the laboratory aim at applying the topics discussed in classroom.

Module 2 (5 cfu)
Selected examples of chemical transformations and functional groups conversions are presented, including reactions related to electrophilic aromatic substitution. Introduction to NMR spectroscopy. The experimental activities developed in the organic chemistry laboratory are aimed at applying the topics discussed in classroom:
the synthesis of an amide of an aromatic carboxylic acid, an example of aromatic heterocycle synthesis, a two steps reaction sequence for the preparation of a substituted aniline, the use of diazonium salt in the preparation of an indicator, a phase transfer-catalyzed transformation.
Finally the determination of an unknown carbonyl compound, the separation of a mixture of two unknown compounds, their recognition and preparation of their suitable derivatives are the topics of the last week in lab.
The characterization of the products will be accomplished by melting point, TLC analysis, IR and NMR spectroscopy.
The common purification techniques for organic compounds are employed: crystallization, acid/base separation, distillation under vacuum, chromatographic separation on a silica gel column.
Prerequisites for admission
Basic knowledge of organic chemistry
Teaching methods
Traditional
Attendance : mandatory
Teaching Resources
Slides on course website

Course web site: http://mbenaglialco.ariel.ctu.unimi.it/v1/home/Default.aspx
Assessment methods and Criteria
Practical (an additional oral assessment is possible upon request of the student). The evaluation will consider both the experimental activities developed individually by each student and the final test, with the aim to verify the skills acquired by the student and his/her ability to work with confidence in a laboratory of Organic Chemistry, and in compliance with the safety rules. Based on the content of the written reports (prepared by the student and describing each experimental activity), the oral assessment will be about the different subjects presented during the course.
Unit: Laboratory of organic chemistry 1
CHIM/06 - ORGANIC CHEMISTRY - University credits: 5
Laboratories: 64 hours
Lessons: 8 hours
Shifts:
Corso A
Professor: Belvisi Laura
Corso B
Professor: Sattin Sara
Unit: Laboratory of organic chemistry 2
CHIM/06 - ORGANIC CHEMISTRY - University credits: 5
Laboratories: 64 hours
Lessons: 8 hours
Shifts:
Professor: Silvani Alessandra
Corso B
Professor: Silvani Alessandra