Pharmacology

A.Y. 2019/2020
8
Max ECTS
64
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The main object of the course is to provide the theoretical and practical basis in order to understand drug action, explaining the concepts of pharmacodynamic and pharmacokinetic. Modern molecular pharmacology will be presented, explaining the molecular targets for drugs and the factors that can affect the therapeutic response. It will be clarified that the interaction drug/organism may have different meanings: (i) be aimed at amending a pathological condition (therapy); (ii) damage the organism (toxicant); (iii) be used to study the organism (medication as a study tool).
Expected learning outcomes
At the end of the course the student will have acquired and understood the basic knowledge in order to understand the interactions between the drugs and the organism. He will have sufficient knowledge of pharmacodynamics and pharmacokinetic to read in a correct and critical way the drug package insert. He will know the molecular mechanisms that can be modulated by drugs. The course is preparatory for the pharmacology courses of the third year, during which the student will apply the acquired knowledge to analyze the different drug classes in relation to pathological conditions.
Course syllabus and organization

Single session

Lesson period
Second semester
Course syllabus
In the educational course of Pharmacology we will cover the concept of Pharmacology, understood as the mutual interaction between a substance introduced into the body and the body itself. This interaction may have different meanings: (i) be aimed at amending a pathological condition (therapy); (ii) damage the organism (toxicant); (iii) be used to study the organism (medication as a study tool).The pathway of a drug from entering the body to its exit will be illustrated (Absorption, distribution, metabolism, elimination) in relation to its characteristics and those of the subjects assuming them (pharmacogenetics). Concept of dose-response, therapeutic index, descriptive pharmacokinetics.
The main knowledges on drugs mechanisms of action (pharmacodynamics), possible targets and drug-drug interactions are explained.
The pharmacodynamic concepts willbe given. Receptors. Quantitative aspects of drug interactions with receptors. Structural and functional families of receptors and intracellular signalling.
Pharmacology of neurotransmission
The rational choice of drug use in specific diseases will be discussed as an example.

[Prerequisiti e modalità d'esame, con riferimento ai descrittori 1 e 2]:
L'esame mira a valutare l'apprendimento dello studente e la sua capacità di capire e scrivere in italiano scientifico. L'esame consta di un unico compito scritto che copre entrambe i moduli, con un unico voto finale. Il compito consta di 40 domande a risposta multipla e alcune domande aperte.

[Lingua di insegnamento]:
Italiano

[Short Course Description]:
In the educational course of Pharmacology we will cover the concept of Pharmacology, understood as the mutual interaction between a substance introduced into the body and the body itself. This interaction may have different meanings: (i) be aimed at amending a pathological condition (therapy); (ii) damage the organism (toxicant); (iii) be used to study the organism (medication as a study tool).The pathway of a drug from entering the body to its exit will be illustrated (Absorption, distribution, metabolism, elimination) in relation to its characteristics and those of the subjects assuming them (pharmacogenetics). Concept of dose-response, therapeutic index, descriptive pharmacokinetics.
The main knowledges on drugs mechanisms of action (pharmacodynamics), possible targets and drug-drug interactions are explained.
The pharmacodynamic concepts willbe given. Receptors. Quantitative aspects of drug interactions with receptors. Structural and functional families of receptors and intracellular signalling.
Pharmacology of neurotransmission
The rational choice of drug use in specific diseases will be discussed as an example
Prerequisites for admission
basic knowledge of biochemistry, physiology and anatomy
Teaching methods
frontal lessons with power point presentation
Teaching Resources
Materiale iconografico in formato digitale fornito dal docente via internet tramite il sito Ariel.
Clementi, Fumagalli - Farmacologia Generale e Molecolare; UTET - Quarta edizione
Clark, Finkel, Rey, Whalen -Le basi della farmacologia; Zanichelli - Seconda edizione italiana
Golan et al., Principi di Farmacologia; Casa Editrice Ambrosiana
Rossi, Cuomo, Riccardi - Farmacologia: principi di base e applicazioni terapeutiche - II edizione, Edizioni Minerva Medica.
Assessment methods and Criteria
The exam is aimed to evaluate the Learning anof the students. The exam coonsists of 40 multiple choices questions
General pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Professor: Popoli Maurizio
Molecular and Cellular Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Lessons: 32 hours
Educational website(s)
Professor(s)
Reception:
Monday, 14.30-16.30; Thursday, 14.30-15.30
via Vanvitelli 32