The course has the aim to increase the knowledge of pharmacology, explaining the mechanisms of action of drugs, and their use in the different pathological conditions. The course will explain that drugs are developed in order to therapeutically treat disease on the basis of the pathological processes present, but also as tools to be applied in the research to understand the pathological basis of diseases. Moreover, the course will present the experimental methodology used to study drugs.
Expected learning outcomes
At the end of the course the student will be able to understand the molecular mechanisms of the different classes of drugs active on the cardiovascular, nervous, endocrine, gastrointestinal systems, of the pharmacological regulation of inflammatory and antineoplastic processes and to apply this knowledge in order to choose the right drug for each pathological condition on the basis of mechanisms. To know and apply the correct experimental methodology in a biomedical laboratory to study drugs.
Lesson period: First semester
(In case of multiple editions, please check the period, as it may vary)
The main general pharmacology concepts will be refreshed (they are mainly discussed in the first level course) and thereafter the different classes of drugs will be illustrated in detail in relation to their application in therapy or as investigational tools. General pharmacology Drugs Adsorption, Distribution, Metabolism, Elimination, Farmacokinetics Receptors and Transporters, Dose-Response Special pharmacology Neurotransmitters, a general view, The Autonomic Nervous System Acetilcholine- Miorelaxant drugs, Catecholamines, Serotonin,Histamine, Nitric Oxide,Aminoacids,Purines CNS Acetilcholine Drugs of the Central nervous system General and Local Anaesthetics Degenerative Diseases Alzheimer, Huntington Chorea, ALS, Parkinson Diseases of Behavior: antipsychotic drugs, Psychotomimetics, Psychostimulants, Antidepressants, Anxiolytics Central myorelaxant drugs Pain and analgesia: Opiates and other analgesics Anticonvulsants Drugs of inflammation Steroids Nonsteroidal anti-inflammatory drugs Histamine
The Cardiovascular System: Diuretics, Vasodilators, drugs for the treatment of Ischemia and heart failure, Antiarrhythmic drugs, antihypertensive drugs Drugs of the Respiratory system Asthma Drugs of the Gastrointestinal system Peptic ulcer and drugs for acid related disorders The endocrine System: a general view Immunoppressant drugs Chemotherapy Antibacterial drugs Antiviral drugs
Prerequisites for admission
Basic knowledge of Human Anatomy, Human Physiology
frontal lessons with power point presentation
Katzung B.G.: "Pharmacology 9th Ed."; Lange Medical Publications Rang H.P., Dale M.M., Ritter J.M.: "Pharmacology 4th Ed"; Churchill Living Stone For reference: Goodman and Gilman's: "The pharmacological basis of therapeutics, 11th Ed."; Pergamon Press.
Assessment methods and Criteria
The exams will be oral on the program explained during the course. The exam will check the knowledge of the different topics, the ability of the student to make connections and to use an adequate scientific language.