Veterinary Pharmacology and Toxicology

A.Y. 2019/2020
9
Max ECTS
80
Overall hours
SSD
VET/07
Language
Italian
Learning objectives
The course provides basic understanding of the principles of drug administration, pharmacokinetics, biotransformation, pharmacodynamics and drug receptor interaction. The course emphasizes drugs belonging to the main pharmacological and chemotherapeutic classes. The pharmacological bases of veterinary therapy are also provided.
Knowledge in veterinary toxicology is also provided with information on sources of intoxications, acute and chronic toxicity, toxicokinetic, metabolism and mechanism of actions of toxic substances, considering species-specific differences
Expected learning outcomes
The student must demonstrate to be able to recognize the mechanisms of action of the drugs used, choose the drug suitable for treatment and its proper management and dispensation in the veterinary field. In addition, the student must be able to recognize the sources of intoxication, metabolism, mechanism of action of the toxicants in the different animal species responsible for acute and chronic poisoning.
Course syllabus and organization

Single session

Responsible
Lesson period
First semester
Prerequisites for admission
In order to take the Veterinary Pharmacology and Toxicology exam, the student must have passed the General Pathology and Microbiology and Veterinary Immunology exams.
Assessment methods and Criteria
Written Exam of Pharmacology and Toxicology
Four questions open for the part of Pharmacology and four questions open for the part of Toxicology.
To pass the exam it is necessary to have enough in both modules (Pharmacology and Toxicology)
The exam does not include an oral exam
Eight annual appeals are made
Farmacologia veterinaria
Course syllabus
The course provides basic understanding of the principles of drug administration, pharmacokinetics, biotransformation, pharmacodynamics and drug receptor interaction. The course emphasizes drugs belonging to the main pharmacological and chemotherapeutic classes. The pharmacological bases of veterinary therapy are also provided.
CREDITS N ° 5
Frontal teaching: 32 hours
Exercise teaching: 8 hours for the whole class
Lessons
History of pharmacology (2 hours)
Kinetics, mechanisms of absorption and distribution of drugs (2 hours)
Metabolism and elimination of drugs (2 hours)
Dynamics, dose response curves, agonists and antagonists (3 hours)
Regulatory Pharmacology, Maximum Residue Limits (2 hours)
Pharmaceutical, routes of administration (1 hour)
Special pharmacology
Autonomic nervous system (1 hour)
Drugs active on adrenergic and cholinergic transmission (2 hours)
CNS active drugs (1 hour)
Local anesthetics (1 hour)
General anesthetics and major tranquilizers (2 hours)
Opioid analgesics (1 hour)
Pharmacology of autacoids (2 hours)
Medicines to control inflammation (2 hours)
Cardiovascular pharmacology (2 hours)
Diuretic and antihistamine drugs (2 hours)
Antibacterial and antiparasitic drugs (2 hours)
Drugs active on the gastrointestinal tract (1 hour)
Respiratory Drugs (1 hour)
Exercises for the whole class (Seminars)
Seminar - Pharmacology Lexicon (2 hours)
Seminar - Veterinary Pharmacovigilance System (2 hours)
Seminar - Pharmaceutical preparations (2 hours)
Seminar - Regulatory (2 hours)
Prof. Petra P. Cagnardi
Exercise teaching in groups of 20 students: 32 total hours divided into 2 exercise blocks of 4 h each to be repeated 4 times.
Block 1
Analytical and extractive methods for the research of drugs from biological matrices (4h)
Block 2
Pharmacokinetic study, Prescription, Pharmacovigilance activity (4h)
Teaching methods
Frontal lessons in pharmacology (4CFU) through presentations of slides and exercises in repeated groups (1CFU) in the laboratory with the use of analytical techniques and software for pharmacokinetic analysis. Practice on prescription and reporting pharmacovigilance.
Teaching Resources
Course slides available on the Teacher's ARIEL website.
Farmacologia Veterinaria - Carli-Ormas-Re-Soldani - Ed. Idelson-Gnocchi
Per consultazione:
Veterinary Pharmacology and Therapeutics - Jim E. Riviere and Mark G. Papich - 9^ Ed. Wiley-Blackwell
A cura di Alfredo Gorio e Anna Maria Di Giulio - Rang & Dale Farmacologia - 8^ Ed. Masson
Tossicologia veterinaria
Course syllabus
General Toxicology
Introduction to Veterinary Toxicology course and classification of toxic compounds (1 hour)
Factors affecting toxicity (1 hour)
Acute and chronic toxicity; Toxicokinetic and Toxicodynamic (2 hours)
3Rs in Toxicology (1 hour)
Epidemiology of Poisonings in different animal species ( 3 hours)
Mutagenesis, cancerogenesis, teratogenesis e reproductive effects (3 hours)
Endocrine Disruptor: definition, effects and toxicity of Endocrine Disruptors (1 hour)
Poisoning in domestic animals by:
Poisonous Plants: alkaloids, glycosides, oxalates containing plants and more, responsible of animal intoxication (4 hours)
Mycotoxins: afaltoxins, ochratoxins and fusariotoxins (fumonisins, trichothecens, zearalenone) (4 hours)
Pesticides and intoxications in domestic animals: herbicides, fungicides, insecticides molluscicides rodenticides (4 hours)
Metals: cadmium, chromium, mercury, lead (4 hours)
Industrial Toxicants: ethylene glycol, petroleum (2 hours)
Miscellaneous (2 hours)
Teaching methods
Frontal lessons in toxicology (4CFU) through slides presentations
Teaching Resources
Didactic materiali is available on ARIEL http://fcalonitv.ariel.ctu.unimi.it/v3/home/Default.aspx
Textbook:
GUPTA R.C. Veterinary toxicology Basic and Clinical principles Third Edition - edited by Elsevier Academic press, 2018
Farmacologia veterinaria
VET/07 - VETERINARY PHARMACOLOGY AND TOXICOLOGY - University credits: 5
Practicals: 16 hours
Lessons: 32 hours
Shifts:
Turno 1 per un gruppo di studenti
Professor: Cagnardi Petra Pico'
Turno 2 per un gruppo di studenti
Professor: Cagnardi Petra Pico'
Turno 3 per un gruppo di studenti
Professor: Cagnardi Petra Pico'
Turno 4 per un gruppo di studenti
Professor: Cagnardi Petra Pico'
Turno per tutti gli studenti
Professor: Villa Roberto Edoardo
Tossicologia veterinaria
VET/07 - VETERINARY PHARMACOLOGY AND TOXICOLOGY - University credits: 4
Lessons: 32 hours
Professor: Caloni Francesca
Professor(s)
Reception:
By appointment from Monday to Friday
Dep. VESPA