Anatomical bases and molecular networks in the Central Nervous system and its pathologies

A.Y. 2020/2021
Overall hours
VET/01 VET/03
Learning objectives
The course aims to provide an understanding of aspects related to the two main integrative systems of the body, the nervous and endocrine systems. Anatomy, function and hormonal regulation of Central and Peripheral Nervous System is covered with developmental anatomy added when applicable.
The course will also provide information about pathogenesis of the most important neurological diseases, and on the animal models that are used for their study and comprehension.
Expected learning outcomes
At the end of the Course the student acquires:
Knowledge and understanding of the the nervous and of the endocrine systems, with specific reference to their anatomy, their function and interactions/regulations as well as well as their pathological alterations.   
Ability to apply knowledge and understanding in critically read the literature and textbooks and use an improved communication skill with scientific terminology.
Course syllabus and organization

Single session

Lesson period
Second semester
Asynchronous lectures will be provided (videos of slides with audio commentary), organized to cover the topics of each lesson of the course. Recorded lectures will be made available on the ARIEL platform. Synchronous meeting will be periodically scheduled via Microsoft TEAMS platform to provide clarifications and insights. Exams will take place on line, in the same way as those taken in person.
Course syllabus
CNS organization; Neurons, Ganglia and Nerves (2 hours)
Internal capsule and ventricles; Willis circulatory system (1 hour)
CNS: Brain and cortical areas, pons, midbrain, diencephalon, basal ganglia, cerebellum (3 hours)
Neurotransmitters and neuromodulators of the SNC. Spinal cord (1 hour)
Ascending pathways, somatosensory systems. Descending pathways, motor systems (1 ora)
Development of the brain, spinal cord, and nerves. (1 hour)
Neurogenic areas in the brain (1 hour)
Gene regulation of neurogenesis, differentiation of neural progenitors. (1 hour)
The neurogenic niche. Engrafting and homing of neural progenitorsi. Neuro-phenotype-related experiments using knock -out mice (2 hours)
Sympathetic System (1 hour),
Paraympathetic System (1 hour),
Enteric (1 hour);
Neuroendocrine: Hypotalamus, Pituitary and Pineal glands (2 hours);
Action Potentials and nervous transmission. Myelinization and salutatory transmission (2 hours)
Synapsis. Neuro-muscular junctions; Eccitatoty and inhibitory Neurotransmitters, Reuptake (3 hours)

Practical training
Microscopy session on Neurons, Ganglia and Nerves (2 hours)
Microscopy session on Neural tissue sections (2 hours)
Microscopy session on Spinal cord (C3;T2,L4) (2 hours)
Confocal images of Pituitary and Pineal glands (2 hours)
Microscopy session on Sciatic Nerve (2 hours)
Gap junctions and Synapsis (2 hours)
Data acquisition and analysis from confocal images (2 hours)
Data acquisition and analysis from MRI images (2 hours)
Prerequisites for admission
Basic knowledge of histology and anatomy
Teaching methods
lectures and practices
Teaching Resources
Assessment methods and Criteria
written exam
Unit: Molecular pathology of the CNS
Practicals: 12 hours
Lessons: 12 hours
Professor: Ceciliani Fabrizio
Unit: Morphology and Function of the CNS
Practicals: 12 hours
Lessons: 24 hours
Professor: Brevini Tiziana
After scheduling via mail
Department of Veterinary Medicine - Room 172