Biomedical sciences 2

A.Y. 2020/2021
5
Max ECTS
50
Overall hours
SSD
BIO/14 MED/04
Language
Italian
Learning objectives
- to indroduce the student to the etiopathogenesis of diseases, with a specific focus on neuropathology
- to acquire basic knowledge about psychiatric drugs, mechanisms of action, therapeutic use, side effects and toxicity
- to acquire basic knowledge about drug interaction
- to acquire basic knowledge about pharmacovigilance and pharmacoepidemiology
Expected learning outcomes
The student will understand how diseases develop and will learn the basics of neuropharmacology.
Course syllabus and organization

Single session

The program and the bibliography are confirmed.
Teaching activities will be held both in presential mode and at distance (synchronous mode) using MS Teams platform.
Assessment of the learning: Moodle (written examination).
Prerequisites for admission
The course has no specific prerequisites
Assessment methods and Criteria
Multiple choice test. The results will be communicated by vweb.
Pharmacology
Course syllabus
1. General principles of pharmacodynamics: drug-receptor interaction and its effect.
2. General principles of pharmacokinetics: absorption, distribution, metabolism and elimination of drugs.
3. General principles of pharmacogenetics: individual variability of response to drugs and toxicity.
4. Drug interactions: interactions between drugs, between drugs and food, between drugs and herbal products.
5. Main mediators, receptors and neurotransmission pathways of the central nervous system involved in the action of drugs.
6. Sedative, hypnotic and anxiolytic drugs.
7. Antidepressant drugs.
8. Antipsychotic drugs.
9. Mood stabilizer drugs.
Teaching methods
Lectures supported by powerpoint presentations.
Teaching Resources
S. Govoni. FARMACOLOGIA. Zanichelli
Experimental medicine and pathophysiology
Course syllabus
General Pathology
1. Homeostasis. Health and disease. Etiology and pathogenesis.
2. Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
3. Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
4. Cell death: necrosis and apoptosis.
5. Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
6. Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
7. Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
8. Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia.

Neuropathology
1. Neuropathology of Down syndrome, phenylketonuria, Rett and X fragile syndrome
2. Neurodegenerative diseases: Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, cerebrovascular diseases. Molecular and genetic bases.
3. Choreas: Huntigton disease, Sydenham chorea. Molecular and genetic features.
4. Ethiopathogenetic and neurochemical aspects of depression and schizophrenia
5. Multiple sclerosis
6. Toxic and metabolic diseases of the Central Nervous System.
Teaching methods
Lectures supported by powerpoint presentations.
Teaching Resources
Patologia generale e neuropatologia
G.M. Pontieri. PATOLOGIA GENERALE E FISIOPATOLOGIA GENERALE. Piccin
J. Maier. PATOLOGIA GENERALE E FISIOPATOLOGIA. Mc GrawHill
Experimental medicine and pathophysiology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 3
Lessons: 30 hours
Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 2
Lessons: 20 hours
Professor: Perrotta Cristiana