The course intends to provide medical students with basic information on drugs' action, focusing on the general principles of pharmacodynamics and pharmacokinetics. To this aim, students will learn about the cellular and molecular targets of drug actions, with emphasis on how the pharmacological interference with these targets can produce a therapeutic outcome. Students will also learn on how a drug reaches its target in the body, crossing physiologic barriers, distributing into peripheral tissues, and eventually being metabolized and excreted.
Expected learning outcomes
Students will develop the aptitude to establish the appropriate pharmacotherapy on the basis of: - Pathogenetic mechanisms of disease - Mechanism of action of the drugs - Pharmacokinetic parameters for the choice of the dose, posology, administration routes -I ndividual characteristics of the patient (comorbidity, possible drug-drug interactions, pharmacogenetics).
Lecture 1: Pharmacodynamics. Classification of drug targets Lecture 2: Pharmacodynamics. Classification of drug targets Lecture 3: Pharmacodynamics. Classification of drug targets Lecture 4: Pharmacodinamics. Quantitative drug-receptor interactions Lecture 5: Pharmacodinamics. Quantitative drug-receptor interactions Lecture 6: Pharmacodinamics- Clinical applications Lecture 7: NO Lecture 8: Arachidonic acid cascade Lecture 9: Pharmacology of immunosuppression Lecture 10: Proton Pump Inhibitors and drugs affecting gastrointestinal functions Lecture 11: Pharmacology of Autonomic Nervous System (ANS) Lecture 12: Pharmacogenetics and pharmacogenomics. Lecture 13: Pharmacokinetics-Absorption Lecture 14: Pharmacokinetics-Distribution Lecture 15: Pharmacokinetics-Metabolism Lecture 16: Pharmacokinetics-Excretion Lecture17: Pharmacokinetics-Clinical applications Lecture 18: Pharmacokinetics- Clinical applications
Prerequisites for admission
To take the Pharmacology 1 exam, students must have already passed all the exams of the first year (Fundamentals of Basic Sciences, Cells Molecules and Genes 1 and 2, Human Body) and the exam of Functions.
Lectures and seminars
· "General and Molecular Pharmacology. Principles of drug action" Edited by Francesco Clementi and Guido Fumagalli. Wiley. · Goodman & Gilman's. "The pharmacological basis of therapeutics". 12th Edition. The McGraw-Hill companies
Assessment methods and Criteria
Students' assessment is based on an oral exam. The exam is deemed to be passed successfully if the final grade is equal to or higher than 18/30. In the event of a full grade (30/30) honors (lode) may be granted. Registration to the exam through SIFA is mandatory.