System Pharmacology
A.Y. 2020/2021
Learning objectives
The course has the aim to increase the knowledge of pharmacology, explaining the mechanisms of action of drugs, and their use in the different pathological conditions. The course will explain that drugs are developed in order to therapeutically treat disease on the basis of the pathological processes present, but also as tools to be applied in the research to understand the pathological basis of diseases. Moreover, the course will present the experimental methodology used to study drugs.
Expected learning outcomes
At the end of the course the student has learned that drugs are developed in order to therapeutically treat disease on the basis of the pathological processes present, but also as tools to be applied in the research to understand the pathological basis of diseases.
He will be able to: i) understand the molecular mechanisms of the different classes of drugs active on the cardiovascular, nervous, endocrine, gastrointestinal systems, of the pharmacological regulation of inflammatory and antineoplastic processes and to apply this knowledge in order to choose the right drug for each pathological condition on the basis of mechanisms; ii) to know and apply the correct experimental methodology in a biomedical laboratory to study drugs. The student will use the knowledge of pharmacokinetics and of the preclinical and clinical trials of drugs to use in a job in the pharmaceutical companies.
He will be able to: i) understand the molecular mechanisms of the different classes of drugs active on the cardiovascular, nervous, endocrine, gastrointestinal systems, of the pharmacological regulation of inflammatory and antineoplastic processes and to apply this knowledge in order to choose the right drug for each pathological condition on the basis of mechanisms; ii) to know and apply the correct experimental methodology in a biomedical laboratory to study drugs. The student will use the knowledge of pharmacokinetics and of the preclinical and clinical trials of drugs to use in a job in the pharmaceutical companies.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
First semester
The lessons will asynchronous, with commented power points uploaded weekly in the Ariel site.
Once every 2 weeks, ( Friday) there will be a synchronous lesson in the TEAMS platform, in order to give explanations.
The criteria to participate in the synchronous lessons will be presented in Ariel.
Once every 2 weeks, ( Friday) there will be a synchronous lesson in the TEAMS platform, in order to give explanations.
The criteria to participate in the synchronous lessons will be presented in Ariel.
Course syllabus
he main general pharmacology concepts will be refreshed (they are mainly discussed in the first level course) and thereafter the different classes of drugs will be illustrated in detail in relation to their application in therapy or as investigational tools.
General pharmacology
Drugs Adsorption, Distribution, Metabolism, Elimination, Farmacokinetics
Receptors and Transporters, Dose-Response
Special pharmacology
Neurotransmitters, a general view, The Autonomic Nervous System
Acetilcholine- Miorelaxant drugs, Catecholamines, Serotonin,Histamine, Nitric Oxide,Aminoacids,Purines
CNS Acetilcholine
Drugs of the Central nervous system
General and Local Anaesthetics
Degenerative Diseases Alzheimer, Huntington Chorea, ALS, Parkinson
Diseases of Behavior: antipsychotic drugs, Psychotomimetics, Psychostimulants, Antidepressants, Anxiolytics
Central myorelaxant drugs
Pain and analgesia: Opiates and other analgesics
Anticonvulsants
Drugs of inflammation
Steroids
Nonsteroidal anti-inflammatory drugs
Histamine
The Cardiovascular System:
Diuretics, Vasodilators, drugs for the treatment of Ischemia and heart failure, Antiarrhythmic drugs, antihypertensive drugs
Drugs of the Respiratory system
Asthma
Drugs of the Gastrointestinal system
Peptic ulcer and drugs for acid related disorders
The endocrine System: a general view
Immunoppressant drugs
Chemotherapy
Antibacterial drugs
Antiviral drugs
General pharmacology
Drugs Adsorption, Distribution, Metabolism, Elimination, Farmacokinetics
Receptors and Transporters, Dose-Response
Special pharmacology
Neurotransmitters, a general view, The Autonomic Nervous System
Acetilcholine- Miorelaxant drugs, Catecholamines, Serotonin,Histamine, Nitric Oxide,Aminoacids,Purines
CNS Acetilcholine
Drugs of the Central nervous system
General and Local Anaesthetics
Degenerative Diseases Alzheimer, Huntington Chorea, ALS, Parkinson
Diseases of Behavior: antipsychotic drugs, Psychotomimetics, Psychostimulants, Antidepressants, Anxiolytics
Central myorelaxant drugs
Pain and analgesia: Opiates and other analgesics
Anticonvulsants
Drugs of inflammation
Steroids
Nonsteroidal anti-inflammatory drugs
Histamine
The Cardiovascular System:
Diuretics, Vasodilators, drugs for the treatment of Ischemia and heart failure, Antiarrhythmic drugs, antihypertensive drugs
Drugs of the Respiratory system
Asthma
Drugs of the Gastrointestinal system
Peptic ulcer and drugs for acid related disorders
The endocrine System: a general view
Immunoppressant drugs
Chemotherapy
Antibacterial drugs
Antiviral drugs
Prerequisites for admission
Basic knowledge of Human Anatomy, Human Physiology
Teaching methods
Power point with comments uploaded in ARIEL.
1 hour/week meeting with TEAMS for explanation
1 hour/week meeting with TEAMS for explanation
Teaching Resources
Katzung B.G.: "Pharmacology 9th Ed."; Lange Medical Publications
Rang H.P., Dale M.M., Ritter J.M.: "Pharmacology 4th Ed"; Churchill Living Stone
For reference: Goodman and Gilman's: "The pharmacological basis of therapeutics, 11th Ed."; Pergamon Press.
Rang H.P., Dale M.M., Ritter J.M.: "Pharmacology 4th Ed"; Churchill Living Stone
For reference: Goodman and Gilman's: "The pharmacological basis of therapeutics, 11th Ed."; Pergamon Press.
Assessment methods and Criteria
The exams will be oral on the program explained during the course on TEAMS platform. The exam will check the knowledge of the different topics, the ability of the student to make connections and to use an adequate scientific language.
BIO/14 - PHARMACOLOGY - University credits: 6
Lessons: 48 hours
Professor:
Sacerdote Paola Giuseppina
Professor(s)
Reception:
Monday, 14.30-16.30; Thursday, 14.30-15.30
via Vanvitelli 32