Clinical biochemistry

A.Y. 2021/2022
Overall hours
Learning objectives
The teaching aims to provide students with theoretical and practical knowledge for the understanding and use of current laboratory tests, through the knowledge of analytical principles, optimization processes and their interpretation.
Expected learning outcomes
At the end of the course, the student will acquire the knowledge of the analytical principles at the base of the most frequent laboratory tests, on the processes for the optimization of laboratory tests, on the current events in the market of national and international diagnostic producers. From a communicative point of view, the student will be able to explain and interpret the chemical-clinical examinations. The course will provide the basic principles to facilitate the future integration of Biologists in the field of Laboratory Medicine.
Course syllabus and organization

Single session

Lesson period
First semester
More specific information on the delivery modes of training activities fo academic year 2021/22 will be provided over the coming months, based on the evolution of the public situation
Course syllabus
General organization of the clinical laboratory
Pre-analytical phase
- biological samples, collection, storage and treatment
- main sourcse of pre-analytical variability
- intra and inter-biological variability
Analytical variability
- analytical characteristics of laboratory methods and their evaluation
- quality assurance
Interpretation of laboratory tests
- reference intervals, decisional limits,
- diagnostic specificity and sensibility, ROC curves
Most common laboratory tests, role of the laboratory in the diagnosis and monitoring of some relevant diseases
- Tests for the evaluation of anemias and iron disorders
- Tests for laboratory management of diabetes
- Dislipidemias
- Tests for liver function
- Tests for kidney function
- Cardiac biomarkers
- Biomarkers for bone disorders
- Serum proteins and inflammation biomarkers
- Principles of clinical enzymology
Prerequisites for admission
It is advisable to have acquired basic knowledges of biochemistry, human anatomy and general physiology.
Teaching methods
The course is based on interactive lessons supported by projected materials. Students are stimulated to actively participate to the lecture/discussion in order to improve their critical spirit. This is achieved by carefully looking at the provided literature and by communicating their concepts in an adequate mode. The attendance to the lectures is strongly advised.
Teaching Resources
The presentations of all the lectures are available through the Ariel website, as well as some suggested readings.
Reference textbooks are the following:
1) Marcello Ciaccio. Elementi di Biochimica Clinica e medicina di laboratorio. EdiSES Università, Napoli,2020.
2) Mauro Panteghini. Interpretazione degli esami di laboratorio. Trattato Italiano di Medicina di Laboratorio. Volume VII. Piccin 2008
Assessment methods and Criteria
Written exam with 3 open questions regarding the topics addressed during the lessons, to be completed in 90 min. The evaluation is based on the achievement of a good knowledge of the matter and on the completeness of answers to all the questions. The ability to present the topics clearly and logically will also be evaluated.
No pre-test or intermediate assays are planned. The results are communicated through the dedicated University web-site.
Lessons: 48 hours
Professor: Paleari Renata
Educational website(s)