Inorganic nanoparticles in life sciences and advanced characterization techniques

A.Y. 2021/2022
8
Max ECTS
64
Overall hours
SSD
CHIM/03 CHIM/06
Language
Italian
Learning objectives
The objective of the course are: 1) to provide the students with the most important knowledge related to basic principles of nanoparticles, their applications and the most relevant analytic technologies related to nanoparticles; 2) learning advanced techniques of organic synthesis and spectroscopic characterization through the attendance of an interdisciplinary theoretical-practical laboratory for the design and implementation of a complex organic synthesis.
Expected learning outcomes
Skills acquired by the students at the end of the course are: 1) knowledge of synthetic methods of inorganic nanoparticles and their functionalization for application in the biomedical field and of the knowledge on the suitable analytic methodologies related to the nanoparticles design; 2) design and implementation of a complex organic synthesis, choice and application of the most appropriate analytical techniques and communication of the obtained results.
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
Teaching methods
The lessons will take place on Microsoft Teams in synchronous mode, at the scheduled times, and will be recorded and made available on the platform. Information on how to access microsoft teams lessons and other teaching instructions will be communicated via institutional email: it is recommended to consult it regularly.
In the event that, taking into account the evolution of the epidemic and compliance with the relevant regulations, it should be possible to carry out activities in presence in the classroom, the students will be promptly informed. In any case, the lessons will be recorded and available online.
Programme and reference material
The course schedule is unchanged.
The reference materials are unchanged.
Assessment methods and evaluation criteria
The assessment methods verification and evaluation criteria will not be changed, the exam will take place in presence or through Microsoft Teams depending on the directives in force at the time of the exam session.
Prerequisites for admission
Good knowledge of organic and inorganic chemistry.
Good knowledge of physics.
Assessment methods and Criteria
Type of exam: written report on the practical part and oral presentation of the results of a bibliographic search on the in-depth study of one of the topics covered in the course.
Inorganic nanoparticles in life sciences
Course syllabus
Introduction to particles and their use. Silicon nanoparticles: synthesis and characterization.
Porous silicon nanoparticles. Synthesis and functionalization.
SEM and TEM microscopy. Carbon dots synthesis and characterization
Carbon dots applications. Porous silica nanoparticles. Gel method
Silica particles and their applications. Degradation and organosilic.
DLS and potential zeta. Iron oxide particles: synthesis and characterization.
Iron oxide particles and their applications in diagnostics and medicine.
Gold particles. Optical and plasmon synthesis and characterization.
Gold particles: functionalization and their applications in diagnostics and medicine.
Particles of silver. Synthesis and properties. Properties such as SERS and antibacterial.
Quantum dots. Synthesis and optical properties. Corona protein.
Polymeric and liposomal particles for vaccines.
Lessons Review of topics and description of laboratory experiences.
Laboratory: Synthesis and characterization (emission, DLS, zeta potential) of gold and silica particles.
Teaching methods
Lectures and laboratory experiences.
Teaching Resources
Lecture notes and bibliographic material provided by the teacher.
Nanoparticle advanced characterization techniques
Course syllabus
Design and implementation of complex organic syntheses through an initial bibliographic research followed by the synthesis of the starting materials, of the catalysts and the realization of the transformation. Choice of the most appropriate analytical techniques and their application to the transformations carried out. Communication techniques on the organization and construction of a report / thesis / article.
Teaching methods
Lectures and laboratory experiences.
Teaching Resources
Lecture notes and bibliographic material provided by the teacher.
Inorganic nanoparticles in life sciences
CHIM/03 - GENERAL AND INORGANIC CHEMISTRY - University credits: 4
Lessons: 32 hours
Professor: De Cola Luisa
Nanoparticle advanced characterization techniques
CHIM/06 - ORGANIC CHEMISTRY - University credits: 4
Lessons: 32 hours
Professor: Rossi Elisabetta