Molecular and Cellular Pharmacology and Experimental Pharmacology

A.Y. 2021/2022
8
Max ECTS
96
Overall hours
SSD
BIO/14
Language
Italian
Learning objectives
The objective of the course is:
- To acquire knowledge about the main pharmacological targets at cellular and molecular level.
- To acquire knowledge about the most relevant in vitro and in vivo experimental models of preclinical pharmacology
- To acquire knowledge about the most relevant experimental techniques of preclinical pharmacology
Expected learning outcomes
At the end of the course, the student will have to know
- the molecular and cellular mechanisms in which the main pharmacological targets are involved
- the techniques available to characterize such biological pathways.
- the main fundamentals of experimental and preclinical pharmacology
- the main techniques used in experimental pharmacology laboratories
Course syllabus and organization

Single session

Responsible
Lesson period
Second semester
Teaching methods
The lectures will be held on the Microsoft Teams platform and can be attended both synchronously based on the timetable of the second semester and asynchronously as they will be recorded and uploaded on that same platform.
In-person laboratory of preclinical pharmacology will be scheduled in accordance with the applicable emergency health regulation.

Course syllabus and Teaching Resources
The contents and reference material will not be changed.

Assessment methods and Criteria
The final exam will be an oral test through the Microsoft Teams platform. The teacher will assess the basic knowledge and the ability of the student to present and discuss the results reported in a scientific publication.
Prerequisites for admission
Knowledge of pharmacology is required to adequately deal with the contents of the course.
Assessment methods and Criteria
Written test and oral presentation of a scientific publication
Molecular and Cellular Pharmacology
Course syllabus
Study of the main pharmacological targets: receptors and channels, structure and function, post-translational modifications, enzymes, proteases and adhesion molecules, synaptic plasticity mechanisms.
Teaching methods
Frontal lectures (16 hours) and laboratory of preclinical pharmacology (32 hours)
Teaching Resources
Slides and other material provided by the professor
Experimental Pharmacology
Course syllabus
Use of PubMed, Entrez, Blast, Genecards and other related websites for protein and gene analysis. Scientific publications. Research integrity. In vitro methods of experimental pharmacology: use and manipulation of cell lines and primary cultures. Human induced pluripotent stem cells (iPSCs) and their use as disease model. Organoids. Molecular biology techniques and SNPs analysis.
Use of animal models of different diseases. Analysis of behavioural experiments.
Microscopy: from traditional fluorescence microscopy to confocal microscopy.
Study of protein-protein interaction.
Teaching methods
Frontal lectures (16 hours) and laboratory of preclinical pharmacology (32 hours)
Teaching Resources
Slides and other material provided by the professor
Experimental Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Practicals: 32 hours
Lessons: 16 hours
Professor: Marcello Elena
Molecular and Cellular Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 4
Practicals: 32 hours
Lessons: 16 hours
Professor: Scheggia Diego