Pharmacology/Toxycology and Legal Medicine

A.Y. 2021/2022
5
Max ECTS
50
Overall hours
SSD
BIO/14 MED/43
Language
Italian
Learning objectives
The course aims to provide the basic notions to:
1. know the working principles of drugs and toxicants at the molecular, cellular and complex systems level
2. know the main parameters and pharmacokinetic variables
3. understand the legal aspects of professional practice, i.e. the duties, the meaning and the legal consequences of acts performed during laboratory and research work
4. know technical and legal aspects of forensic toxicology
Expected learning outcomes
The student will acquire the terminology and knowledge related to the molecular aspects of the mechanisms of drugs. This knowledge will be complemented by notions of pharmacokinetics, which will be useful to better understand the problems related to the correct use of drugs.
Students will be able to understand the basics of the Italian legal system, the legal consequences of negligence, malpractice and imprudence or wilful behaviour; the duties related to the practice of the profession (professional secrecy, informed consent, duty to inform the authorities), acts aimed at proactively minimize legal risks, the principles of accountability. The students will also be able to understand the basic principles of forensic genetics in criminal and paternity testing settings, as well as the duty to protect personal data.
Course syllabus and organization

Single session

Responsible
- The program of the course will not be modified
- Teaching resources will not be modified
- Teaching method: on-line teaching on Microsoft Teams platform
- Assessment method: written on-line exam
Prerequisites for admission
Pharmacology: the student must have previously acquired knowledge of anatomy, physiology and pathology. This knowledge should be acquired in the courses of previous years

Legal Medicine: the subject is approached for the first time
Assessment methods and Criteria
The final vote will be the weighted average on the CFU of the 2 modules.
The exam is organized in a written and an oral test.
The written test consists of open questions and multiple choice quiz questions
Pharmacology
Course syllabus
Therapeutic and toxic compounds
Pharmacokinetics: Absorption, Distribution, Metabolism and Elimination of Drugs
Pharmaceutical formulations: characteristics and purpose
Molecular Mechanisms of Drug action
Receptors: structure-activity relationships, quantitative aspects of drug interactions
Pharmacodynamics variability: individual and population
The Autonomic and Central Nervous System: neurotransmission
Cholinergic and adrenergic transmission: organitation, receptors and signal transduction
Pharmacological effects of agonists and antagonistis and adverse effects.
5-HT (serotonin) transmitter: Physiological system and receptors, agonist and antagonists drugs
HIstamine and Inflammation transmitters: Physiological system and receptors, agonist and antagonists drugs
Endogenous opioids system: agonists and receptors
Nitrous oxide: Physiological system and receptors, drugs
Anti-inflammatory ,antipyretic and analgesic agents
General principles of antimicrobial therapy:
mechanisms and classes of chemotherapic agents
mechanisms and classes of antiviral agents
Chemotherapy of neoplastic disease
Teaching methods
Frontal lessons supported by visual tools. All the material presented in class will be available to the student and uploaded to the Ariel platform
Teaching Resources
Farmacologia generale e speciale per le Lauree sanitarie. Ed. Piccin
Farmacologia 7°ed ELSEVIER
Principi di Farmacologia - Le basi fisiopatologiche della terapia. ed. Ambrosiana
Forensic medicine
Course syllabus
Basics of the Italian legal system
The code of Ethics
Malpractice and accountability. Imprudence, wilful behaviour, negligence and their legal consequences
The duties for the Laboratory Technician:
- professional secrecy
- informed consent for adults and minors
- duty to inform the authorities
The legal status of biological samples
Definition of forensic Sciences
Principles of forensic genetics in criminal and paternity testing settings
Laws of protection of personal data.
Teaching methods
Frontal lessons supported by visual tools. All the material presented in class will be available to the student and uploaded to the Ariel platform
Teaching Resources
Cazzaniga, Cattabeni, Luvoni, Zoja Compendio di Medicina legale e delle Assicurazioni (XIV Ed.), UTET, 2018
ISBN 978-88-5981875-5

Materiale di studio verrà fornito dai docenti a lezione.
Forensic medicine
MED/43 - FORENSIC MEDICINE - University credits: 2
Lessons: 20 hours
Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 3
Lessons: 30 hours