Radiomics

A.Y. 2021/2022
6
Max ECTS
48
Overall hours
SSD
MED/04 MED/36
Language
English
Learning objectives
Undefined
Expected learning outcomes
Undefined
Course syllabus and organization

Single session

Responsible
More specific information on the delivery modes of training activities for academic year 2021/22 will be provided over the coming months, based on the evolution of the public health situation.
Course syllabus
1. Radiobiology

Interactions of ionising radiation with matter
Radiation effects on healthy and tumour tissue
Radiosensitivity and radioresistance of tissue

2. Imaging acquisition techniques

Digital diagnostic images: matrix, spatial resolution, contrast resolution, archive and distribution
Processing of digital images
Ultrasound
- Mechanical waves and ultrasound image formation
- Doppler phenomenon
- Ultrasound contrast media and harmonic imaging
Computerized tomography
- Technological evolution of the equipment, reconstruction through sinograms and back projection
- Hounsfield unit and window concept
Magnetic Resonance
- Signal genesis, relaxation time T1 and T2, spatial encoding
- Contrast agents in radiology and MR

3. Oncological radiotherapy

Imaging for radiotherapy
Indications to radiotherapy in the most common solid tumors and hematological malignancies
Radiotherapy devices and modalities
Work flow in radiotherapy
Image guided radiotherapy
Tumour remission and normal tissue toxicity
Clinical research in oncology. How to write a scientific paper?
Radiomic applications in clinical Radiation Oncology
Journal club on clinical cases

4. Images are numbers

Discovering DICOM attributes - overview of anonymization strategies
Radiomic goals
Radiologic images are biomarkers for oncologic response evaluation and for response prediction
Radiomic pathways
Image normalization techniques
Target lesions identification
Target lesions contouring
Atlas-based autosegmentation
Extraction of target lesions
Radiomic analysis
Radiomic features description
Radiomic features variability and causes of variability
Influence of image acquisition parameters

5. Radiomics and radiogenomics

Clinical applications
Treatment personalisation
Methodological challenges

6. Basics of statistics for radiomics
How to set-up a robust radiomic study from a statistical perspective
How to recognize biases and how to mitigate their effect
Methods of statistical analysis

7. New frontiers in radiomics

Studies with phantoms
Dosomics
Deep learning for medical image analysis
Prerequisites for admission
No prior knowledge is required.
Teaching methods
The course is based on frontal lessons. Lectures could be held in presence and/or online (Microsoft Teams). Lectures will be accompanied by practicals, group work and time for reflection and collective discussion.
Teaching Resources
Radiomics and Radiogenomics: Technical Basis and Clinical Applications (Imaging in Medical Diagnosis and Therapy) 1st Edition
By Ruijiang Li, Lei Xing, Sandy Napel, Daniel L. Rubin
ISBN 9780815375852
Published June 28, 2019 by Chapman and Hall/CRC
Assessment methods and Criteria
Oral examination on the items that have been described during classes.
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 0
MED/36 - IMAGING AND RADIOTHERAPY - University credits: 0
Lessons: 48 hours