The major aim of the course will be to deepen the knowledge of chemotherapy and neuropsychopharmacology as well as the pharmacological aspects of the drugs most commonly used in either fields. The main classes of chemotherapic drugs (antibiotics, anticancer drugs) and drugs used for the treatment of psychiatric diseases (antidepressants, antipsychotics, anxiolytics, drugs for the treatment of bipolar disorder) will be investigated. Of both classes, some original scientific articles will be discussed with interactive critical discussion.
Expected learning outcomes
At the end of the course, the student must demonstrate to have learned the rationale for the therapeutic use of both macro-classes of drugs, deepening their mechanism of action and side effects, appropriately assessing their risk/benefit. Particular attention will be paid to the interactions and the possible manifestation of resistance to their use.
Examination at once or divided into parts At once Methods of assessing knowledge Oral examination Vote Vote verbalized (from 1/30 to 30/30)
1. Introduction to the course. General concept of microbiology and antibiotic therapy 2. Antibiotiocs: antimetabolites,sulfonamides, trimetoprim. 3. Antibiotics that inhibit the synthesis of bacterial wll: penicillin and chephalosporin 4. Antibiotics that inhibit protein synthesis: aminoglycosides, tetracyclines, chloramphenicol, macrolides. 5. Antibiotics that inhibit nucleic acid synthesis: rifampicin, fluoroquinolones 6. Antibiotic resistance 7. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy 8. Antimalarials 9. Immunomodulators 10.Viruses and Antiviral therapy 11. Antiretroviral Agents and Treatment of HIV Infection 12. Treatment of Viral Hepatitis (HBV/HCV) 13. COVID and chemotherapy 13. General Principles in the Pharmacotherapy of Cancer 14. Antitumor drugs. Alkylating Anticancer drugs and platinum cordination complexes 15. Antibiotics . 16. Antimetabolites 17. Topoisomerase inhibitors 18: Hormonal therapy 17.Targeted therapyv(imatinib, gefitinib, bortezomib) 18. Chemoresistance to cancer therapy 19. New approaches: biothecnological drugs 20. Drug interaction in oncology
· Basic and Clinical Pharmacology 14/e (LANGE Basic Science) 2018 Bertram Katzung · Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017 Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann
How to organize an experimental research in the field of neuropsychopharmacology: criteria and principles. Acquisition of data from the scientific literature; structure and analysis of scientific works; consultation of databases. Preparation of a scientific manuscript in the neuropsychopharmacological field. Validity of the use of in vitro methods for the study of neuropsychopharmacology: use of cell cultures Validity of the use of in vivo methods for the study of neuropsychopharmacology: use of laboratory animals (rodents). Use of laboratory animals: legislation and criteria. In vivo test for the determination of pharmacological activity, related to selected classes of drugs. Biological variability; statistical elaboration and analysis of the experimental results. Study methods for psychiatric diseases: genetic models and environmental models. Biomarkers in psychiatric research and their clinical implications. General considerations and applications. Study methods of drugs with antidepressant activity Study methods of drugs with antipsychotic activity Methods of study of drugs with analgesic activity Study methods of drugs with anxiolytic and hypnotic activity Study of substance and non-substance addiction. Animal models for the study of drugs of abuse and methods for the study of drugs that act on the mechanisms of gratification. Methods for identifying new drugs of abuse and how to study them. Study methods of drugs for neurodegenerative diseases. Study methods of drugs of natural origin with application in the field of neuropsychopharmacology Imaging techniques applied to neuropsychopharmacology.
- Basic and Clinical Pharmacology 14/e (LANGE Basic Science) 2018 Bertram Katzung - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e 2017 Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann