Anatomic Pathology

A.Y. 2023/2024
6
Max ECTS
80
Overall hours
SSD
MED/08
Language
Italian
Learning objectives
The course aims to provide students with the tools to learn the pathological basis of organ and apparatus diseases and to be able to integrate macroscopic changes, histological and cytological modifications and molecular alterations into the clinical picture. The course will also describe the main diagnostic procedures in surgical pathology, the professional tasks, responsibilities and fields of activity of the pathologist. Teaching approach will be strictly integrated with that applied in the pathology modules of the system disease courses.
Expected learning outcomes
At the end of the course, the student has to
· become acquainted with the most important diagnostic tools (exfoliative and aspirative cytology, histology, cytology, frozen section) and techniques (immunohistochemistry and molecular pathology) of the surgical pathology;
· be aware of the possible applications of such tools in preventive medicine (cytological and molecular screening), in clinical diagnostics and in the evaluation of prognostic and predictive parameters;
· be able to properly interpret and integrate in the clinic the information provided by the pathology report for an appropriate therapeutic decision-making process.
Single course

This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.

Course syllabus and organization

Linea: Policlinico

Course syllabus
PRINCIPAL PROCEDURES AND TECHNIQUES in PATHOLOGy - Cytological and histological examinations; frozen intraoperative examinations. Histological, histochemical, immunohistochemical and molecular biology techniques - Notess on mortuary police regulation and autopsy.
CARDIOVASCULAR PATHOLOGY - Arteriosclerosis. Pathological bases, macro- and microscopic evolutionary aspects and complications of myocardial infarction, heart attack and chronic ischemic heart disease.
RESPIRATORY PATHOLOGY - Alveolar and interstitial pneumonia. Pneumoconiosis. Lung granulomatous disease. Primary and post-primary tuberculosis. - Histological and cytological diagnosis of lung cancer, histological classification of lung cancers, tumor stages and evaluation of predictive parameters of response to systemic treatments - Pleural mesothelioma.
PATHOLOGY OF THE DIGESTIVE TRACT - Cancers of the salivary glands. Classification and morphology of precancerous lesions of the oral cavity, esophagus, stomach and intestine - Morphological bases and tumor stage of oral, esophageal, gastric and intestinal cancers - Definition and histological classification of the polyps of the large intestine - chronic and acute pancreatitis. Histological classification of exocrine and endocrine tumors of the pancreas - chronic blood stasis, chronic hepatitis, cirrhosis and primary liver cancers.
PATHOLOGY OF THE HEMATOPOIETIC AND LYMPHOID SYSTEMS - Differential diagnosis of lymphadenitis - Classifications of Hodgkin's and nonHodgkin's lymphomas. - Pathological stage of lymphomas, diagnostic role of bone marrow aspiration and biopsy
ENDOCRINE PATHOLOGY - morphological bases of thyroid nodules, histological classification and characteristics of thyroid cancers; validity and limitations of cytological diagnosis - morphological bases of differential diagnosis between hyperplasia, benign and malignant tumors in endocrine pathology
PATHOLOGY OF URINARY TRACT AND MALE GENITAL SYSTEM - Acute and chronic nephritis and glomerulonephritis. Morphological features of kidney failure. Histological classification, morphological characteristics, evolution and stage of kidney and bladder cancer. Benign hyperplasia and prostate cancer. Testicular cancers.
NEUROPATHOLOGY - Morphological features of increased intracranial pressure (anatomical and pathological bases of hydrocephalus) - Hetiogenesis, morphology and evolution of intracranial hemorrhages and cerebral infarction - Pathological bases of brain infectious diseases (meningitis, meningoencephalitis, encephalitis, abscesses) - Histological classification and diagnosis of intracranial tumors.
DERMATOPATOLOGY - Basocellular and squamocellular carcinomas - morphological characteristics of benign nevi, dysplastic nevi and melanomas. Minimum criteria for differential diagnosis - Histological classification and staging systems of melanomas.
PATHOLOGY OF BONE AND SOFT TISSUES - Classification and pathological characteristics of bonetumors (osteoma, osteochondroma, chondroma, osteosarcoma, chondrosarcoma, giant cell cancer and Ewing's tumor - Histogenesis, morphological criteria of benignity and malignancy, grading of soft tissue sarcomas.
BREAST PATHOLOGY - Differential diagnosis of breast lumps- Epidemiology, pathogenesis, evolution, histological classification and pathological prognostic factors of breast cancer - Diagnostic role of cytology by fine needle aspiration, needle biopsy and intraoperative examination. Predictive factors of response to different systemic treatments.
PATHOLOGY OF FEMALE GENITAL TRACT- Definition of CIN, dysplasia, koilocytosis, in situ carcinoma, micro-invasive and invasive cervical carcinoma - Role of HPV in cancer etiopathogenesis. Prevention and early diagnosis strategies for cervical cancer - hyperplasia and endometrial cancers. Uterine leiomyoma and leiomyosarcoma- Ovarian tumors -Pathology of pregnancy.
Prerequisites for admission
Human Anatomy, Physiology, General Pathology
Teaching methods
Frontal lessons supported by visual means. Professional training activities in the Department
Teaching Resources
V. Kumar, A.K. Abbas, N. Fausto, J.C. Aster: Robbins e Cotran - Le basi patologiche delle malattie.
Assessment methods and Criteria
Oral test
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 48 hours
: 16 hours
Shifts:
Gruppo 1
Professor: Bosari Silvano
Gruppo 2
Professor: Vaira Valentina
Gruppo 3
Professor: Vaira Valentina
Gruppo 4
Professor: Vaira Valentina
Turno
Professor: Bosari Silvano

Linea: San Donato

Responsible
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 48 hours
: 16 hours
Professor: Pruneri Giancarlo

Linea: San Giuseppe

Responsible
MED/08 - PATHOLOGY - University credits: 6
Informal teaching: 16 hours
Lessons: 48 hours
: 16 hours
Professor: Pelosi Giuseppe
Educational website(s)
Professor(s)
Reception:
Monday 12.00-13.00 (by appointment)
Interhospital Pathology Division, Science and Technology Park, Via Fantoli 16/15, 20138 Milano