Biomedical Sciences 2
A.Y. 2023/2024
Learning objectives
- to indroduce the student to the etiopathogenesis of diseases, with a specific focus on neuropathology
- to acquire basic knowledge about psychiatric drugs, mechanisms of action, therapeutic use, side effects and toxicity
- to acquire basic knowledge about drug interaction
- to acquire basic knowledge about pharmacovigilance and pharmacoepidemiology
- to acquire basic knowledge about psychiatric drugs, mechanisms of action, therapeutic use, side effects and toxicity
- to acquire basic knowledge about drug interaction
- to acquire basic knowledge about pharmacovigilance and pharmacoepidemiology
Expected learning outcomes
The student will understand how diseases develop and will learn the basics of neuropharmacology.
Lesson period: First semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course can be attended as a single course.
Course syllabus and organization
Single session
Responsible
Prerequisites for admission
Biomedical Sciences 1
Assessment methods and Criteria
Multiple choice test. The results will be communicated by web.
Pharmacology
Course syllabus
1. General principles of pharmacodynamics: drug-receptor interaction and its effect.
2. General principles of pharmacokinetics: absorption, distribution, metabolism and elimination of drugs.
3. General principles of pharmacogenetics: individual variability of response to drugs and toxicity.
4. Herbal products and supplements.
5. Drug interactions: interactions between drugs, between drugs and food, between drugs and herbal products/supplements.
6. Clinical drug development and generic drugs.
7. Pharmacovigilance.
8. Main mediators, receptors and neurotransmission pathways of the central nervous system involved in the action of drugs
2. General principles of pharmacokinetics: absorption, distribution, metabolism and elimination of drugs.
3. General principles of pharmacogenetics: individual variability of response to drugs and toxicity.
4. Herbal products and supplements.
5. Drug interactions: interactions between drugs, between drugs and food, between drugs and herbal products/supplements.
6. Clinical drug development and generic drugs.
7. Pharmacovigilance.
8. Main mediators, receptors and neurotransmission pathways of the central nervous system involved in the action of drugs
Teaching methods
Lectures supported by powerpoint presentations
Teaching Resources
K. Whalen. Le basi della farmacologia. Ed. Zanichelli.
S. Govoni. FARMACOLOGIA. Zanichelli
S. Govoni. FARMACOLOGIA. Zanichelli
Experimental medicine and pathophysiology
Course syllabus
1. Homeostasis. Health and disease. Etiology and pathogenesis.
2. Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
3. Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
4. Cell death: necrosis and apoptosis.
5. Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
6. Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
7. Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
8. Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia.
Neuropathology
1. Neuropathology of Down syndrome, phenylketonuria, Rett and X fragile syndrome
2. Neurodegenerative diseases: Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, cerebrovascular diseases. Molecular and genetic bases.
3. Choreas: Huntigton disease, Sydenham chorea. Molecular and genetic features.
4. Ethiopathogenetic and neurochemical aspects of depression and schizophrenia
5. Multiple sclerosis
6. Toxic and metabolic diseases of the Central Nervous System. Viruses and the SNC
2. Basic Immunology: innate and acquired immunity. Functions and disorders of the immune system.
3. Cell injury: biochemical and molecular mechanisms. Causes of cell injury: hypoxia and ischemia, free radicals.
4. Cell death: necrosis and apoptosis.
5. Inflammation and repair. Overview of inflammation. Acute inflammation: reaction of blood vessels, recruitment of leukocytes and phagocytosis. Mediators of inflammation: histamine, nitric oxide, PAF, arachidonic acid derivatives, complement system, cytokines and chemokines. Chronic inflammation: morphologic patterns, mediators, granulomas. Tissue regeneration and repair: healing of skin wounds and fibrosis.
6. Atherosclerosis and its complications. Stroke and TIA among the causes of aphasias.
7. Cell adaptation: hypertrophy, hyperplasia, hypertrophy, athrophy, metaplasia.
8. Neoplasia. Characterization of benign and malignant neoplasms. Cellular and molecular hallmark of cancer. Cancerogenesis: chemical, radiation and microbial carcinogens. Metastasis. Angiogenesis. Clinical aspects of neoplasia.
Neuropathology
1. Neuropathology of Down syndrome, phenylketonuria, Rett and X fragile syndrome
2. Neurodegenerative diseases: Alzheimer and Parkinson diseases, frontotemporal lobar degeneration, cerebrovascular diseases. Molecular and genetic bases.
3. Choreas: Huntigton disease, Sydenham chorea. Molecular and genetic features.
4. Ethiopathogenetic and neurochemical aspects of depression and schizophrenia
5. Multiple sclerosis
6. Toxic and metabolic diseases of the Central Nervous System. Viruses and the SNC
Teaching methods
Lectures supported by powerpoint presentations
Teaching Resources
Di Nuzzo-Gradini. Fisiopatologia del SNC. Piccin, 2017
Maier JA. "Patologia generale e fisiopatologia 2/ed. per le professioni sanitarie" Mc Graw Hill Education, 2014
Maier JA. "Patologia generale e fisiopatologia 2/ed. per le professioni sanitarie" Mc Graw Hill Education, 2014
Experimental medicine and pathophysiology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 3
Lessons: 30 hours
Professors:
Castiglioni Sara, Maier Jeanette Anne Marie
Pharmacology
BIO/14 - PHARMACOLOGY - University credits: 2
Lessons: 20 hours
Professor:
Perrotta Cristiana
Educational website(s)
Professor(s)