Functional Genomics and Bioinformatics

Functional Genomics is the field of molecular genetics that is involved with assigning function and interactions to genes and their products and ranges from the detailed study of individual genes to large scale experimental approaches designed to capture genome wide effects and interactions. The aim of the course is to provide students a thorough overview of recent high-tech analytical approaches in molecular genetics, which have revolutionized genomics. In particular, Next Generation Sequencing has wide application to many functional genomics settings. Students of the Molecular Biotechnology and Bioinformatics Laurea Magistrale also follow an additional teaching unit of 4 CFU, where a range of these applications, are introduced, focusing on the nature of data generated, its strengths and limitations as well as computational and statistical approaches used to analyse genomic and transcriptomic datasets in various contexts. Practical sessions focusing on the use of the R programming language provide hands on experience of analysing genome-wide datasets, giving students the perspective required design, interpret and critically appraise large scale functional genomics studies and providing the foundation for the development of specific specialized expertise in bioinformatics.
The course is ideally linked to those dealing with bioinformatics and genetics.

After following this course, the students will have a deep knowledge about the latest genome wide and single gene approaches to study gene functions in model organisms. Teaching is especially focused on helping students gain the expertise required to decide which approaches and technologies to use to investigate biological pathways and the function of genes involved in them.