General Comparative Pathology and Laboratory Analysis
A.Y. 2023/2024
Learning objectives
Aim of Comparative General Pathology and Laboratory Analyses is to provide students with knowledge related to causes and mechanisms of disease, at a cellular and tissue level with possible general involvement. Knowledge concerning pathophysiology and the main defensive systems of the animal and their failure in course of disease will be provided as well. Examples with particular emphasis on the comparative aspects of disease mechanisms in companion animals will be shown. Along with theoretical information, aim of the course is to introduce students to the techniques employed in a diagnostic laboratory, from the execution to the interpretation of specific analyses able to recognize pathological and physiopathological conditions in companion animals, to be applied for the disease prevention.
Expected learning outcomes
Students are expected to learn mechanisms, causes and consequences of inflammatory, degenerative, adaptative, neoplastic and metabolic disorders on the animal system, including the pathophysiological changes associated with these diseases (e.g blood changes, fever) and possible differences among animal species. Dysfunctions of the immune system will be learned as well.
Students will be also able to apply the main techniques of the diagnostic biological laboratory, including the interpretation of laboratory results and the identification of blood cells in different animal species.
Students will be also able to apply the main techniques of the diagnostic biological laboratory, including the interpretation of laboratory results and the identification of blood cells in different animal species.
Lesson period: Second semester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Second semester
Course syllabus
THEORETICAL LECTURES
Concepts of homeostasis and disease (1 hour)
General etiology: genetically determined diseases; radiation (photodynamic diseases); chemical causes of disease; living agents; nutrition (deficiencies and excesses) (6 hours)
Review of cellular degenerative processes (e.g. steatosis) and extracellular processes (e.g. amyloidosis) (3 hours)
Adaptive mechanisms (hyper and hypotrophy, hyper and hypoplasias, metaplasias) (1 hour)
Cellular death: necrosis and apoptosis (1 hour)
The inflammatory process: acute and chronic inflammation; fever (8 hours)
Immunopathology: hypersensitivity phenomena and autoimmune diseases (4 hours)
Review of pathology of the endocrine system: pancreas, pituitary, thyroid, Stress: endocrine and metabolic modifications; (5 hours)
Pathophysiology of blood. Changes in red and white blood cells, jaundice (5 hours)
Circulation disorders (2 hours)
Review on tumors. Etiology of tumors (4 hours)
Quality assurance in the veterinary laboratories (4 hours)
Manual and automated Hematological techniques (6 hours)
Blood chemistry techniques and urinalysis (6 hours)
Elements of molecular pathology: inflammation and its protagonists (chemotaxis, phagocytosis and killing) (4 hours)
Elements of molecular pathology: molecular methodologies applied to the study of pathology (4 hours)
PRACTICAL LECTURES
Recognition of cells and organ morphological alterations relating to the main pathologies/preanalytical phase in the skill lab (2 hours)
Use of scientific databases for bibliographic searches (2 hours)
Laboratory practice (groups of 15-20 students)
Manual hematological procedures and preparation of other biological samples (4 hours)
Microscopy practice (groups of 15-20 students)
Evaluation of normal blood smears in different species (2 hours)
Recognition of pathological pictures in blood of different species (2 hours)
Molecular techniques for the quantification of cytokines (qPCR) (4 hours)
Concepts of homeostasis and disease (1 hour)
General etiology: genetically determined diseases; radiation (photodynamic diseases); chemical causes of disease; living agents; nutrition (deficiencies and excesses) (6 hours)
Review of cellular degenerative processes (e.g. steatosis) and extracellular processes (e.g. amyloidosis) (3 hours)
Adaptive mechanisms (hyper and hypotrophy, hyper and hypoplasias, metaplasias) (1 hour)
Cellular death: necrosis and apoptosis (1 hour)
The inflammatory process: acute and chronic inflammation; fever (8 hours)
Immunopathology: hypersensitivity phenomena and autoimmune diseases (4 hours)
Review of pathology of the endocrine system: pancreas, pituitary, thyroid, Stress: endocrine and metabolic modifications; (5 hours)
Pathophysiology of blood. Changes in red and white blood cells, jaundice (5 hours)
Circulation disorders (2 hours)
Review on tumors. Etiology of tumors (4 hours)
Quality assurance in the veterinary laboratories (4 hours)
Manual and automated Hematological techniques (6 hours)
Blood chemistry techniques and urinalysis (6 hours)
Elements of molecular pathology: inflammation and its protagonists (chemotaxis, phagocytosis and killing) (4 hours)
Elements of molecular pathology: molecular methodologies applied to the study of pathology (4 hours)
PRACTICAL LECTURES
Recognition of cells and organ morphological alterations relating to the main pathologies/preanalytical phase in the skill lab (2 hours)
Use of scientific databases for bibliographic searches (2 hours)
Laboratory practice (groups of 15-20 students)
Manual hematological procedures and preparation of other biological samples (4 hours)
Microscopy practice (groups of 15-20 students)
Evaluation of normal blood smears in different species (2 hours)
Recognition of pathological pictures in blood of different species (2 hours)
Molecular techniques for the quantification of cytokines (qPCR) (4 hours)
Prerequisites for admission
Knowledge of animal biochemistry, anatomy, physiology and microbiology is required for a more proficient students' learning
Teaching methods
The course is based on lectures, lab trainings in hematology, biochemistry, microscopy and molecular diagnostics.
Teaching Resources
The reference material for students' education is represented by the slides projected during the lectures. The final exam is based on these presentations as well. Presentations will be uploaded on the teacher's Ariel webpage in advance. Possible updated scientific articles will be provided by the teachr
Assessment methods and Criteria
The final examination is written and questions are based only on the topics faced during the course. The exam schedule is 60 minutes.
The structure of the final exam is the following: ten multiple choice questions, three list questions and two short essay questions.
For each correct answer in the MCQs and for each correct information int list questions and short essays, 1 point is assigned. No negative scores are given.
The maximum score is 30. The minimum passing score is 18. A quality control step following the final examination, is also applied in order to check questions that achieved very low pass rates. In case of errors in the questions and very low overall pass rates, the minimum passing score can be lowered.
The results of the examinationa are published on the course Ariel website (in terms of list of badge numbers of successful candidates with relative scores). The student has 3 days to inform the teacher of his intention to refuse the grade
The structure of the final exam is the following: ten multiple choice questions, three list questions and two short essay questions.
For each correct answer in the MCQs and for each correct information int list questions and short essays, 1 point is assigned. No negative scores are given.
The maximum score is 30. The minimum passing score is 18. A quality control step following the final examination, is also applied in order to check questions that achieved very low pass rates. In case of errors in the questions and very low overall pass rates, the minimum passing score can be lowered.
The results of the examinationa are published on the course Ariel website (in terms of list of badge numbers of successful candidates with relative scores). The student has 3 days to inform the teacher of his intention to refuse the grade
VET/03 - VETERINARY PATHOLOGY - University credits: 9
Practicals: 16 hours
Lessons: 64 hours
Lessons: 64 hours
Shifts:
Professors:
Giordano Alessia, Lecchi Cristina
1 TURNO PER GRUPPO DI STUDENTI
Professor:
Martini Valeria2 TURNO PER GRUPPO DI STUDENTI
Professor:
Martini Valeria3 TURNO PER GRUPPO DI STUDENTI
Professor:
Martini Valeria4 TURNO PER GRUPPO DI STUDENTI
Professor:
Lecchi Cristina5 TURNO PER GRUPPO DI STUDENTI
Professor:
Lecchi Cristina6 TURNO PER GRUPPO DI STUDENTI
Professor:
Lecchi CristinaTURNO UNICO PER TUTTI DI STUDENTI
Professor:
Giordano AlessiaEducational website(s)
Professor(s)
Reception:
Monday to friday, on request (via e-mail)
Teacher's office
Reception:
upon appointment
Via dell'Università 6, Lodi
Reception:
from Monday to Friday, on request