Medicinal Chemistry 2

The course aims at providing the most relevant concepts related to the design, synthesis, physico-chemical and stereo-electronic properties, mechanism of action, therapeutic application and side effects of the drugs belonging to the investigated classes. In particular, lectures will deal with the structure-activity relationships and the approaches applied in medicinal chemistry to optimize the pharmacodynamic profile and the pharmacokinetic properties of drugs. Based on the fundamentals acquired in the course of Medicinal and Toxicological Chemistry 1, in the present course the student should accomplish a good overall background in medicinal chemistry, through the study of drugs acting on the central and peripheral nervous system, the cardiovascular and anti-histamine drugs, the non-steroidal anti-inflammatory agents.

Expected learning outcomes (nuovo testo da inserire in W4)
Knowledge and understanding. The course aims to ascertaining the student's knowledge of the approaches and methods presented during the lectures, particularly those related to the structural aspects of drugs, their genesis and their therapeutic classification.
Applying knowledge and understanding. During the exam, the student should be able to apply knowledge and understanding, in particular by appropriately discussing the main aspects of the structure/synthesis of the main compounds of a class of drugs, together with their related therapeutic utility.
Making judgements. The student will answer any question with pertinence and criticism, both in the written and oral part of the exam. In their answers, students are frequently requested to motivate their own choices.
Communication. During the exam, the student will demonstrate to explain and develop concepts with clarity, synthesis and language skills. Clarity of presentation and communication skills are part of the overall evaluation.
Lifelong learning skills. The main objective of the course is that to ascertain the strengthening of the student's background in Medicinal Chemistry: the acquired competence will help the student's informed choice (professionalizing courses/thesis lab) towards completing the educational path.