Generazione di modelli di malattie umane e loro applicazione

The objective is to provide knowledge on the strategies that are used to choose an experimental
model that can be used in the study of human diseases. The importance of a multidisciplinary path
will be underlined, and some examples of human diseases and the experimental models used
according to the various phases of the study will be analysed, i.e. characterization of the molecular
and cellular mechanism of the disease, followed by preclinical analysis. The course will focus on
aspects related to cell growth, such as ribosomopathies and on cell biology.

The expected learning outcomes include the ability to reason about the choice of an experimental
model, which allows students to critically evaluate the different options available and select the most
appropriate one for the specific context. Furthermore, it is essential that students understand the
limitations and cost-benefit ratio of each model, allowing them to make informed decisions that
balance effectiveness and available resources. Finally, the ability to design the choice of a model is
essential to develop innovative and practical solutions, ensuring that students are able to plan and
implement complex projects successfully.