Genetic and molecular bases of diseases

Relevant objectives of the first part of the course are to provide content concerning the organization of the human genome and the genetic and epigenetics mechanisms involved in genome mutation and in control of gene expression. The molecular mechanisms learned in the first part of the course will help to understand the regulation of specific function of the immune system and the pathogenesis of the immune diseases with perspective of gene therapy, as well as the pathogenetic basis of genetic diseases and cancer, topics covered in the second part of the course.

Acquiring competence on molecular mechanisms regulating genome plasticity and activity will allow to achieve the comprehension of molecular mechanisms underlying both constitutional monogenic and polygenic diseases, and cancer. Furthermore, experimental activities in labs, will give suitable skills to learn the current methods applied in molecular diagnosis of genetic diseases.