Precision Pharmacology and Gender Therapy

Modulo- Medicina di Genere - Gender Therapy
At the end of the course, students have to demonstrate they possess the basic knowledge of gender differences and know how to decline them within the pathophysiological contexts addressed in the course.
Modulo: Farmacologia di precisione - Precision Pharmacology
The course aims at providing students with the theoretical basis for understanding emerging precision pharmacology approaches that take into account gender and individual variability, with regard to both genetic, environmental and lifestyle characteristics. Examples will highlight how the combination of genomic and behavioral profiles with pharmacokinetic and pharmacodynamic data can enable the identification of therapies acting directly and highly specifically on the cause of diseases in single individuals as well as in selected subpopulations of patients. Practical sessions will focus on the impact of genetic polimorphisms on pharmacological responses.

Modulo- Medicina di Genere - Gender Therapy
At the end of the course, students have to demonstrate they possess the basic knowledge of gender differences and know how to decline them within the pathophysiological contexts addressed in the course.
Modulo: Farmacologia di precisione - Precision Pharmacology
At the end of the course, the student will be able to: 1) define how genetic and environmental profiles can influence individual responses to pharmacological agents; 2) predict the necessary changes that should be made to a drug's dosage in order to reduce its side effects and/or optimize its efficacy, and test whether and how already marketed drugs may be used for new and different therapeutic indications ("repurposed" drugs); 3) test how diagnostic and prognostic biomarkers of disease, already in use or recently introduced, can be employed to predict the in vivo action of drugs; 4) critically interpret data on the effects of pharmacological agents taking into account available pharmacogenomic information; 5) use genetic databases and critically analyze data reported in the scientific literature.