Physics, Statistics and Radioprotection

A.Y. 2026/2027
9
Max ECTS
90
Overall hours
SSD
MEDS-22/A MEDS-24/A PHYS-06/A
Language
Italian
Learning objectives
The course aims to provide the basic notions to:
1. develop models of physical phenomena through a basic application of the scientific method.
2. know the fundamental principles of physics and their implications in the biomedical field, especially as regards the working principles of some lab techniques.
3. solve simple physics problems about topics related to the biomedical field and give quantitative estimates of the phenomena.
4. know the main statistical techniques for the evaluation of precision and accuracy of measurement methods used in biomedical labs.
5. inform those, subjected to diagnostic imaging or radio-treatment, about the risks connected to radiations and about the practices to avoid unnecessary exposure.
Expected learning outcomes
At the end of the course, the student should be able to:
1. Assign a unit of measurement and estimate the order of magnitude of various physical quantities of biomedical interest or everyday life (number of cells in human body, volume of blood, volume of a room)
2. Observe and measure physical phenomena (a falling body, a flowing fluid, a propagating light ray) and develop models to mathematically describe them, through a basic application of the scientific method
3. Explain the fundamental principles of mechanics, fluid dynamics, thermodynamics, electromagnetism and optics
4. Explain the relevance and the implications of such principles for physiological and biomedical phenomena
5. Describe the working princples of common diagnostic devices and lab techniques (e.g. electrophoresis, centrifuge, flow cytometry)
6. Solve simple quantitative problems about the described phenomena, identifying the main elements and possible approximations (e.g. finding forces acting on a body and deciding whether to neglect friction in the description of its motion)
At the end of the course of Medical Statistics students are expected to:
- evaluate accuracy and precision of measurement tools currently used in laboratory activities
- analyze laboratory data using descriptive and inferential statistics
- understand a report including methods and results on laboratory data
- write a report including description of statistical methods and results.
The student will learn the basic information of radiation protection to be able to work in an environment where ionizing radiations are present.
Single course

This course can be attended as a single course.

Course syllabus and organization

Single session

Responsible
Prerequisites for admission
The student must have basic knowledge of algebra and elements of geometry.
Assessment methods and Criteria
The exam consists of a written test with open questions and multiple choice questions about applied physics, medical statistic, diagnostic imaging and radiotherapy. A calculator and probability distributions table, available on myAriel, are allowed. The results will be provided to the students via myAriel. To succeed, the student must have a positive evaluation in all the three parts of the exam. The final score is the CFU-weighted average of the three parts, rounded up. In the Applied Physics module, up to 5 points will be assigned based on the Team-Based Learning activities during the lectures. The evaluation is a grade expressed out of thirty.
Applied physics
Course syllabus
Preliminary tools ∙ Fundamental and derived quantities, International System ∙ Multiples and submultiples, scientific notation and significant figures ∙ Estimates of orders of magnitude ∙ Scalar and vector quantities ∙ Vector operations Mechanics ∙ Uniform straigth motion, uniformly accelerated motion ∙ Principles of dynamics ∙ Forces: gravitational, weight, constraint reaction, friction, elastic ∙ Motion on an inclined plane, 2D motion ∙ Work of a force ∙ Kinetic energy theorem ∙ Conservative forces, potential energy ∙ Conservation of mechanical energy ∙ Dissipative forces ∙ Types of deformation ∙ Stress-strain curves, Young modulus ∙ States of matter Fluids ∙ Pressure ∙ Stevin's law ∙ Archimedes force ∙ Flow rate ∙ Hydrodynamic focusing (flow cytometry) ∙ Bernoulli's theorem ∙ Viscosity ∙ Poiseuille's equation ∙ Viscous friction and terminal velocity ∙ Centrifugation, electrophoresis ∙ Termodynamics ∙ Ideal gas ∙ Absolute temperature ∙ Equation of state for perfect gases ∙ Working principle and calibration of a micropipette ∙ Osmotic pressure ∙ Real gases ∙ Principles of thermodynamics ∙ Latent and specific heat ∙ Conduction, convection and irradiation ∙ Human metabolism Elettromagnetism and optics ∙ Electric charge ∙ Coulomb's force and electric field ∙ Electric potential ∙ Conducting and insulating materials ∙ Electric current ∙ Electric resistance ∙ Joule effect ∙ Magnetic field ∙ Propagation of electromagnetic waves ∙ Wavelength and frequency ∙ Absorbance and DNA/protein dosage ∙ Fluorescence ∙ Light scattering ∙ Flow citometry ∙ Geometric optics: reflection and refraction ∙ Refractive index ∙ Dispersion ∙ Optical biosensors ∙ Lenses and image formation ∙ Resolution limit in an optical system ∙ Optical microscope
Teaching methods
Frontal lessons with blackboard and projector (slides and movies). Slides of the lectures and exercises are available on myAriel. Homeworks are assigned and discussed during the following classes. Some topics will be discussed within the Team-Based Learning apprach, with assigned material to be studied at home and group activities during the lectures
Teaching Resources
Suggested books are for reference only. The student should use lecture notes and can freely choose on which books to study the discussed topics. For all lectures, slides and additional materials will be provided via myAriel. APPLIED PHYSICS - Giambattista "College physics" McGraw-Hill - McKay "Physics for the Life Sciences" vol II
Medical statistics
Course syllabus
Reliability of a measure ∙ Reliability and its components ∙ Systematic error and casual error Variability ∙ Between-subjects and within-subjects variability Descriptive statistics ∙ Graphs ∙ Location, scale, and shape of a frequency distribution ∙ Measures of location and scale ∙ Accuracy and precision of a measure ∙ Quantiles and reference limits ∙ Correlation and Kappa statistic Gaussian model ∙ Probability of events on the population within the Gaussian model ∙ How to model the error with a Gaussian model Inference ∙ Sampling variability ∙ Population and sample ∙ Estimate of a population parameter with sampling quantities Sampling distribution ∙ The central limit theorem and the distribution of a sampling quantity ∙ Standard error Confidence interval ∙ Definition and meaning ∙ Formulas Hypothesis testing ∙ First type and second type errors and power of a test ∙ Sample size calculation ∙ Clinical statistics and clinical relevance ∙ Hypothesis testing on a population mean Deterministic and probabilistic models ∙ Deterministic and probabilistic models: differences ∙ Simple linear regression model: interpretation and parameters ∙ Hypothesis testing on the parameters of a simple linear regression model
Teaching methods
Frontal lessons with blackboard and projector (slides and movies). Slides of the lectures and exercises are available on myAriel. Some training sessions are held in the computer lab.
Teaching Resources
Suggested books are for reference only. The student should use lecture notes and can freely choose on which books to study the discussed topics. For some topics, slides and additional materials will be provided via myAriel - Pagano - Gauvreau "Principles of Biostatistics", Chapman and Hall/CRC - Bland "An Introduction to Medical Statistics" (English Edition) 4th Edition, Oxford University Press - Katz, JG. Elmore, DMG. Wild, S. Lucan "Epidemiology, Biostatistics, Preventive Medicine, and Public Health", Elsevier
Diagnostic imaging and radiotherapy
Course syllabus
Physical Principles of Diagnostic Imaging and Radiotherapy ∙ Structure of the atom ∙ Classification of nuclides ∙ Definition of radiation ∙ Electromagnetic radiation ∙ Wavelength and frequency ∙ Photons ∙ The electromagnetic spectrum ∙ X-rays and gamma rays ∙ Particulate radiation ∙ Ionizing radiation ∙ Characteristic X-rays ∙ Bremsstrahlung X-rays ∙ Production of X-rays in diagnostic imaging ∙ Nuclear stability and radioactivity ∙ Radioactive decay ∙ The law of radioactive decay ∙ Mean life and half-life ∙ Activity ∙ Alpha, beta−, beta+, and gamma decay ∙ Electron capture decay ∙ Interaction of different types of radiation with matter ∙ Interaction of charged alpha and beta particles ∙ Collisions ∙ Energy loss by deceleration (stopping power) ∙ Interaction of alpha particles ∙ Bragg curve ∙ Interaction of beta particles ∙ Positron-matter interaction: annihilation ∙ Interaction of beta particles ∙ Photoelectric effect, Compton scattering, and pair production ∙ Attenuation of X-ray and gamma-ray beams ∙ Law of attenuation ∙ Radiation detection systems ∙ Equivalent dose to an organ ∙ Effective whole-body dose ∙ Radiation Protection in Healthcare ∙ ALARA principle (As Low As Reasonably Achievable) ∙ Principle of justification ∙ Optimization process ∙ Diagnostic Reference Levels (DRLs) ∙ Equipment ∙ Acceptance criteria for equipment ∙ Protection during pregnancy and breastfeeding ∙ Dose communication ∙ Purpose of radiation protection ∙ Dose limits for members of the public ∙ Worker classification criteria ∙ Category A and Category B exposed workers ∙ Dose limits for occupationally exposed workers ∙ Physical and medical surveillance ∙ Area classification ∙ Internal and external exposure ∙ Sources of risk in radiological activities ∙ Personal protective equipment (PPE) ∙ Safety in radiological practice ∙ Radiobiology ∙ Physical, chemical, and biological phases of radiation action ∙ Radiation protection regulations in medical imaging ∙ Study of the action and effects of ionizing radiation on biological structures ∙ Experimental techniques in radiobiology ∙ Sequence of radiobiologically relevant events ∙ Radiation-induced cellular damage ∙ Diagnostic Imaging Techniques ∙
Teaching methods
Frontal lessons with blackboard and projector (slides and movies).
Teaching Resources
Suggested books are for reference only. The student should use lecture notes and can freely choose on which books to study the discussed topics. For most topics, slides and additional materials will be provided via myAriel.
Modules or teaching units
Applied physics
PHYS-06/A - Physics for Life Sciences, Environment, and Cultural Heritage - University credits: 4
Lessons: 40 hours
Professor: Zanchetta Giuliano
Shifts:
Turno
Professor: Zanchetta Giuliano

Diagnostic imaging and radiotherapy
MEDS-22/A - Imaging and Radiotherapy - University credits: 1
Lessons: 10 hours
Professor: Messina Carmelo
Shifts:
Turno
Professor: Messina Carmelo

Medical statistics
MEDS-24/A - Medical Statistics - University credits: 4
Lessons: 40 hours
Shifts:
Turno
Professor: Edefonti Valeria Carla

Professor(s)
Reception:
For meetings, please write an email.
via Celoria, 22, 20133 Milano
Reception:
On appointment
LITA Segrate or online