Biochemistry of signal transduction and membrane biophysics
A.A. 2018/2019
Obiettivi formativi
To provide the students with the cultural and methodological tools for the critical analysis, and the understanding, of the molecularmechanisms and electrical signals governing communication from outside to inside the cell and from cell to cell.
Risultati apprendimento attesi
Non definiti
Periodo: Secondo semestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Informazioni sul programma
Powerpoint slides and original papers will be available of the dedicated Ariel website.
Prerequisiti
Good knowledge of molecular and cell biologyand of the basic principle of Physics is highly recommended.
Exam modality
Unit 1: oral.Students will have to criticallyanalyze, in the form of an oral presentation, a scientific paper chosen among the ones made available by the teachers.The presentation, consisting in a short introduction of the biological problem, and the critical analysis of the experiments reported in the paper, will be followed by discussion with the teacher on the signaling mechanisms analysed in the research article.
Unit2: the exam will consist in an oral test on topics discussed during the course.
Exam modality
Unit 1: oral.Students will have to criticallyanalyze, in the form of an oral presentation, a scientific paper chosen among the ones made available by the teachers.The presentation, consisting in a short introduction of the biological problem, and the critical analysis of the experiments reported in the paper, will be followed by discussion with the teacher on the signaling mechanisms analysed in the research article.
Unit2: the exam will consist in an oral test on topics discussed during the course.
Metodi didattici
The classes will have a classical format with lessons given by the teachers during which the students will be stimulated to actively participate with questions and comments related to the considered subject.
Attendance is highly recommended.
Attendance is highly recommended.
Unità didattica: signal transduction
Programma
Unit 1 - Signal Transduction 3 cfu - borrowed from the course of Molecular Biology of the Cell (BIOLOGIA MOLECOLARE DELLA CELLULA)
This module of the course focuses on mechanisms of intracellular signal transduction in animal cells. We will analyze specific topics on different well-characterized signaling pathways, and important, useful experimental approaches to study signal transduction. The course will also have in-depth discussion of specific topics in the signaling field.
General principles of signal transduction
Signaling by Tyrosine kinase receptors: the Insulin receptor
mTOR signaling and translational control
Cellular and molecular responses to cell stress signals
Critical analysis of research articles related to the course's topics
This module of the course focuses on mechanisms of intracellular signal transduction in animal cells. We will analyze specific topics on different well-characterized signaling pathways, and important, useful experimental approaches to study signal transduction. The course will also have in-depth discussion of specific topics in the signaling field.
General principles of signal transduction
Signaling by Tyrosine kinase receptors: the Insulin receptor
mTOR signaling and translational control
Cellular and molecular responses to cell stress signals
Critical analysis of research articles related to the course's topics
Materiale di riferimento
All the material used for the classes will be made available at the dedicated Ariel website.
Unità didattica: membrane biophysics
Programma
Unit 2 - Membrane biophysics 3 cfu
This module will cover basic aspects of membrane biophysics: role of lipids and proteins; membrane microdomains and lipid-protein interactions; lipid rafts and caveolae; principles of ions movements; passive and active properties of the plasma membrane; Ion channel structure and function; generation of the electrical signals in excitable cells, conduction of the action potentials; the neuromuscular junction; biomembranes in excitation contraction coupling in cardiac and skeletal muscles.
This module will cover basic aspects of membrane biophysics: role of lipids and proteins; membrane microdomains and lipid-protein interactions; lipid rafts and caveolae; principles of ions movements; passive and active properties of the plasma membrane; Ion channel structure and function; generation of the electrical signals in excitable cells, conduction of the action potentials; the neuromuscular junction; biomembranes in excitation contraction coupling in cardiac and skeletal muscles.
Materiale di riferimento
All the material used for the classes will be made available at the dedicated Ariel website.
Moduli o unità didattiche
Unità didattica: membrane biophysics
FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA) - CFU: 3
Lezioni: 24 ore
Docente:
Barbuti Andrea Francesco
Unità didattica: signal transduction
FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA) - CFU: 3
Lezioni: 24 ore
Docente:
Costa Alex
Docente/i
Ricevimento:
Giovedì 14:00-16:00
Dipartimento di Bioscienze 3° Piano Torre C