Cancer immunology (ONC)
A.A. 2018/2019
Obiettivi formativi
Acquisition of immunosurveillance and immunoevasion concepts, knowledge of the biological basis of the most tumor escape mechanisms, understanding of the biological rational understanding of the most used approaches for the modulation of the immune response with anti-cancer purposes.
Risultati apprendimento attesi
Specific knowledge on the relationship between the host's immune system and the tumor and the main anti-tumor approaches based on immunomodulatory strategies.
Periodo: Terzo trimestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Terzo trimestre
Prerequisiti
Acute and chronic inflammation, the immune system, tumor immunogenicity, molecular pathogenesis of solid and hematological malignancies.
Test based on a series of questions
Test based on a series of questions
General pathology and immunology
Programma
The immune system in the tumor microenvironment:
Inflammation in tumor progression;
Functional role of tumor-associated leukocytes and other host cells;
Immune infiltrate and tumor angiogenesis;
Effects of the tumor on local and systemic immune regulation;
Tumor-associated regulatory T cells;
Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN);
Tertiary lymphoid structures in the tumor;
Therapeutic approaches targeting the tumor microenvironment.
Inflammation in tumor progression;
Functional role of tumor-associated leukocytes and other host cells;
Immune infiltrate and tumor angiogenesis;
Effects of the tumor on local and systemic immune regulation;
Tumor-associated regulatory T cells;
Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN);
Tertiary lymphoid structures in the tumor;
Therapeutic approaches targeting the tumor microenvironment.
Materiale di riferimento
PDF files of the lessons. Review article on different topics.
Medical oncology
Programma
Cancer immunology and immunotherapy in solid tumors:
History and principles of immune cancer treatment;
Predictors of response to immune therapies;
Development of anticancer immune agents;
Evidence of efficacy of immune therapies;
Immunotherapies in different models of solid cancers;
T-cell therapies;
Cancer vaccines;
Future trends in cancer immune therapy;
Toxicity of cancer immune therapies;
Sustainability of anticancer agents.
History and principles of immune cancer treatment;
Predictors of response to immune therapies;
Development of anticancer immune agents;
Evidence of efficacy of immune therapies;
Immunotherapies in different models of solid cancers;
T-cell therapies;
Cancer vaccines;
Future trends in cancer immune therapy;
Toxicity of cancer immune therapies;
Sustainability of anticancer agents.
Materiale di riferimento
PDF files of the lessons. Review article on different topics.
Blood diseases
Programma
Cancer immunology and immunotherapy in hematological tumors:
The role of checkpoint inhibitors in Lymphomas;
Adoptive immunotherapy for cancer (CAR T cells);
Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer;
The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma;
The role of the B-cell receptor signaling in lymphoid malignancies.
The role of checkpoint inhibitors in Lymphomas;
Adoptive immunotherapy for cancer (CAR T cells);
Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer;
The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma;
The role of the B-cell receptor signaling in lymphoid malignancies.
Materiale di riferimento
PDF files of the lessons. Review article on different topics.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore
Docenti:
Corradini Paolo, Neri Antonino
General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 2
Lezioni: 14 ore
Docenti:
Chiaramonte Raffaella, Locati Massimo
Medical oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore
Docente/i
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Istituto Nazionale dei Tumori - via G. Venezian, 1
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Laboratori area Pieve c/o Istituto Clinico Humanitas
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Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3,Milano