Cancer immunology (ONC)
A.Y. 2018/2019
Learning objectives
Acquisition of immunosurveillance and immunoevasion concepts, knowledge of the biological basis of the most tumor escape mechanisms, understanding of the biological rational understanding of the most used approaches for the modulation of the immune response with anti-cancer purposes.
Expected learning outcomes
Specific knowledge on the relationship between the host's immune system and the tumor and the main anti-tumor approaches based on immunomodulatory strategies.
Lesson period: Third trimester
Assessment methods: Esame
Assessment result: voto verbalizzato in trentesimi
Single course
This course cannot be attended as a single course. Please check our list of single courses to find the ones available for enrolment.
Course syllabus and organization
Single session
Responsible
Lesson period
Third trimester
General pathology and immunology
Course syllabus
The immune system in the tumor microenvironment:
Inflammation in tumor progression;
Functional role of tumor-associated leukocytes and other host cells;
Immune infiltrate and tumor angiogenesis;
Effects of the tumor on local and systemic immune regulation;
Tumor-associated regulatory T cells;
Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN);
Tertiary lymphoid structures in the tumor;
Therapeutic approaches targeting the tumor microenvironment.
Inflammation in tumor progression;
Functional role of tumor-associated leukocytes and other host cells;
Immune infiltrate and tumor angiogenesis;
Effects of the tumor on local and systemic immune regulation;
Tumor-associated regulatory T cells;
Tumor-associated suppressor cells of the myeloid lineage (MDSC, TAM, TAN);
Tertiary lymphoid structures in the tumor;
Therapeutic approaches targeting the tumor microenvironment.
Medical oncology
Course syllabus
Cancer immunology and immunotherapy in solid tumors:
History and principles of immune cancer treatment;
Predictors of response to immune therapies;
Development of anticancer immune agents;
Evidence of efficacy of immune therapies;
Immunotherapies in different models of solid cancers;
T-cell therapies;
Cancer vaccines;
Future trends in cancer immune therapy;
Toxicity of cancer immune therapies;
Sustainability of anticancer agents.
History and principles of immune cancer treatment;
Predictors of response to immune therapies;
Development of anticancer immune agents;
Evidence of efficacy of immune therapies;
Immunotherapies in different models of solid cancers;
T-cell therapies;
Cancer vaccines;
Future trends in cancer immune therapy;
Toxicity of cancer immune therapies;
Sustainability of anticancer agents.
Blood diseases
Course syllabus
Cancer immunology and immunotherapy in hematological tumors:
The role of checkpoint inhibitors in Lymphomas;
Adoptive immunotherapy for cancer (CAR T cells);
Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer;
The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma;
The role of the B-cell receptor signaling in lymphoid malignancies.
The role of checkpoint inhibitors in Lymphomas;
Adoptive immunotherapy for cancer (CAR T cells);
Allogenic hematopoietic stem cell transplantation as adoptive immunotherapy in cancer;
The targeting of cancer microenvironment (T-reg, MDSC, NK, Dendritic, macrophages): the paradigma of multiple myeloma;
The role of the B-cell receptor signaling in lymphoid malignancies.
Blood diseases
MED/15 - BLOOD DISEASES - University credits: 2
Lessons: 14 hours
Professors:
Corradini Paolo, Neri Antonino
General pathology and immunology
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY - University credits: 2
Lessons: 14 hours
Professors:
Chiaramonte Raffaella, Locati Massimo
Medical oncology
MED/06 - MEDICAL ONCOLOGY - University credits: 2
Lessons: 14 hours
Professors:
De Braud Filippo Guglielmo Maria, Siena Salvatore
Professor(s)
Reception:
by appointment +39 02 6444.2291
Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3,Milano