Epidemiology, pathogenesis and diagnostics of cancer
A.A. 2018/2019
Obiettivi formativi
The training course aims to transfer to the students the basic knowledge of tumors pathogenesis and diagnosis, with particular reference to the development of the epidemiology, pathology and medical genetics notions and their applications to the diagnosis and therapy of tumors.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
growth
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
In particular:
- Comprehension of the frequency and distribution of tumors and the environment influence on tumor
growth
- Concepts of cancer stem cells, their biology, functional pathways, involved genes and their instability
- Concepts of solid tumors and hematological malignancies, their biology, and the molecular diagnostics applied to their assessment.
Risultati apprendimento attesi
Epidemiology of cancer
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors
Molecular mechanisms of cancer pathogenesis
Alteration of cancer cell biology
Molecular classification of solid and hematological tumors
Approaches for diagnosis of solid and hematological tumors
Periodo: Terzo trimestre
Modalità di valutazione: Esame
Giudizio di valutazione: voto verbalizzato in trentesimi
Corso singolo
Questo insegnamento non può essere seguito come corso singolo. Puoi trovare gli insegnamenti disponibili consultando il catalogo corsi singoli.
Programma e organizzazione didattica
Edizione unica
Responsabile
Periodo
Terzo trimestre
Prerequisiti
Principles of tumorigenesis: causes and modality
Genetic instability, deregulated cell proliferation and survival of cancer cell
Key deregulated molecular pathways
Molecular diagnostic tools
Multiple Choice Test Questions
Genetic instability, deregulated cell proliferation and survival of cancer cell
Key deregulated molecular pathways
Molecular diagnostic tools
Multiple Choice Test Questions
Medical statistics
Programma
Patterns and trends of cancer mortality in Europe.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
Tobacco and cancer risk.
Alcohol and cancer.
Other environmental risk factors of cancer, including nutrition and diet.
Materiale di riferimento
Pdf files of presentations. Review article on different topics.
General pathology and immunology
Programma
Cancer Stem Cells:
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated secretory phenotype.
Identification and origins. Biologic characteristic of cancer stem cells. Cancer stem cell niches. Regulation of cancer stem cells by the tumor microenvironment and cytokine networks.
Cancer cell growth: nutrient regulation, control of tumor growth and metabolism, pathways that control cell growth, es. mTOR.
Autophagy: Autophagy-mediated tumor suppression; tumor promotion by autophagy; role of autophagy in cancer therapy.
Cellular Senescence: Biochemical and morphological characteristics of senescent cells; causes of senescence; premature senescence. Major pathways regulating senescence. Tumor promoting and tumor suppressing activity of senescence-associated secretory phenotype.
Materiale di riferimento
Pdf files of presentations. Review article on different topics.
Medical Oncology
Programma
Natural history of solid cancer; Cancer clinical methodology; Building state of the art in oncology;
Principles of cancer multidisciplinary treatment; Principles of medical cancer treatment; Biology-driven therapy in solid cancer: the model of colon cancer; Molecularly targeted therapy: the model of GIST.
Principles of cancer multidisciplinary treatment; Principles of medical cancer treatment; Biology-driven therapy in solid cancer: the model of colon cancer; Molecularly targeted therapy: the model of GIST.
Materiale di riferimento
Pdf files of presentations. Review article on different topics.
Blood diseases
Programma
Molecular and biological mechanisms of acute and chronic myeloid disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Molecular and biological mechanisms of lymphoproliferative disorders. Diagnostic tools- Concept of risk stratification
Materiale di riferimento
Pdf files of presentations. Review article on different topics.
Moduli o unità didattiche
Blood diseases
MED/15 - MALATTIE DEL SANGUE - CFU: 2
Lezioni: 14 ore
Docente:
Neri Antonino
General pathology and immunology
MED/04 - PATOLOGIA GENERALE - CFU: 1
Lezioni: 7 ore
Docente:
Chiaramonte Raffaella
Medical Oncology
MED/06 - ONCOLOGIA MEDICA - CFU: 2
Lezioni: 14 ore
Medical statistics
MED/01 - STATISTICA MEDICA - CFU: 1
Lezioni: 7 ore
Docente:
La Vecchia Carlo Vitantonio Battista
Docente/i
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Fondazione IRCCS Istituto Nazionale Tumori, Milano
Ricevimento:
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Ospedale San Paolo, via di Rudinì 8, Milano. Blocco C, 7° piano.
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